Table 3 Top URs predicted by the IPA at 24 h and 48 h after NDL treatment of MCF-7 cells
Upstream Regulator | Molecule Type | p value | z-score | Upstream Regulator | Molecule Type | p-value | z-score |
|---|---|---|---|---|---|---|---|
24 h | 48 h | ||||||
Activated | |||||||
Doxorubicin | chemical drug | 1.2E-16 | 3.32 | TP53 | transcription regulator | 9.8E-50 | 5.38 |
Cigarette smoke | chemical toxicant | 2.8E-15 | 2.07 | CDKN1A | kinase | 1.3E-48 | 4.11 |
TNF | cytokine | 1.6E-13 | 2.27 | NUPR1 | transcription regulator | 1.6E-32 | 6.43 |
Hydrogen peroxide | chemical - endogenous mammalian | 1.9E-11 | 2.07 | Calcitriol | chemical drug | 1.6E-30 | 4.73 |
NFE2L2 | transcription regulator | 1.0E-10 | 2.68 | Doxorubicin | chemical drug | 6.1E-23 | 3.33 |
Inhibited | |||||||
SFTPA1 | transporter | 4.5E-09 | −2.45 | RABL6 | other | 1.9E-38 | −5.40 |
Actinomycin D | chemical drug | 4.6E-09 | −2.13 | ERBB2 | kinase | 1.0E-29 | −2.37 |
N-acetyl-L-cysteine | chemical drug | 1.8E-06 | −2.36 | E2F1 | transcription regulator | 5.4E-28 | −3.41 |
SB203580 | chemical - kinase inhibitor | 3.5E-06 | −2.37 | Beta-estradiol | chemical - endogenous mammalian | 7.7E-28 | −2.02 |
CSF2 | cytokine | 2.0E-27 | −5.58 | ||||