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Table 5 Effects of Lepisanthes rubiginosa L. on castor oil-induced diarrhea in mice

From: Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves

Group

n

Onset of diarrhea (mean ± SEM, min)

Number of stools after 4 h

(mean ± SEM)

Inhibition of defecation (%)

Control (1% tween-80 water)

5

33.0 ± 3.59

22.80 ± 1.63

 

Standard (Loperamide 3 mg/kg)

5

197.4 ± 2.65***

2.60 ± 0.50***

88.59

Extract 250 mg/kg

5

101.0 ± 3.64***

9.60 ± 0.74***

57.89

Extract 500 mg/kg

5

178.8 ± 5.00***,†††

5.20 ± 0.58***,††

77.19

  1. Here, *p < 0.05, **p < 0.01 and ***p < 0.001 when compared with control group. †† p < 0.01 and ††† p < 0.001 when compared with Extract 250 mg/kg group. SEM: standard error of mean