Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial

Lopez, H. L.; Habowski, S. M.; Sandrock, J. E.; Raub, B.; Kedia, A.; Bruno, E. J.; Ziegenfuss, T. N.

doi:10.1186/s12906-017-1977-8

BMC Complementary Medicine and Therapies

Table 7 VAS secondary measures

From: Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex^®) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial

Visit	AyuFlex1 (n = 28)	AyuFlex2 (n = 33)	Placebo (n = 25)	p value
		*Overall Knee Mobility*		Overall^a	AF1 + AF2 vs PBO	AF1 vs PBO	AF2 vs PBO	AF1 vs AF2
Overall^a				0.577	0.552	0.344	0.946	0.341
0	69.4 (±21.2)	69.4 (±17.6)	68.8 (±21.8)
14	68.0 (±22.1)	75.8 (±16.2)	68.0 (±21.8)		0.324	0.892	*0.048*	0.078
42	75.5 (±16.3)	78.2 (±14.9)	70.1 (±21.6)		0.078	0.249	0.078	0.474
84	79.0 (±16.3)	83.4 (±14.9)	73.3 (±18.8)		0.031	0.208	*0.021*	0.251
Changes to Measures of Overall Knee Mobility^b
	9.6 (±21.6)	13.9 (±18.9)	4.6 (±17.9)	0.201	0.115	0.351	0.074	0.391
		*Overall Joint Function*		Overall^a	AF1 + AF2 vs PBO	AF1 vs PBO	AF2 vs PBO	AF1 vs AF2
Overall^a				0.444	0.199	0.219	0.367	0.776
0	73.3 (±20.5)	66.6 (±23.8)	72.0 (±20.8)
14	74.8 (±17.9)	76.0 (±18.0)	72.6 (±20.2)		0.304	0.718	0.158	0.448
42	76.2 (±15.1)	79.0 (±19.0)	72.6 (±22.6)		0.388	0.493	0.059	0.226
84	81.1 (±13.0)	82.2 (±17.9)	72.0 (±20.8)		0.387	0.055	0.015	0.522
Changes to Measures of Overall Joint Function^b
	7.8 (±21.1)	15.5 (±24.7)	0.0 (±21.1)	*0.038*	*0.029*	0.215	*0.011*	0.182
		*Overall Low Back Health*		Overall^a	AF1 + AF2 vs PBO	AF1 vs PBO	AF2 vs PBO	AF1 vs AF2
Overall^a				0.828	0.630	0.907	0.446	0.732
0	64.2 (±22.9)	64.3 (±26.6)	54.4 (±24.6)
14	71.8 (±18.3)	68.3 (±23.4)	55.8 (±21.2)		*0.032*	*0.017*	0.153	0.405
42	74.5(±22.5)	72.4 (±23.1)	55.8 (±21.2)		*0.007*	*0.014*	*0.024*	0.626
84	76.6 (±20.9)	76.5 (±23.3)	59.8 (±24.4)		*0.013*	*0.029*	*0.037*	0.978
Changes to Measures of Low Back Health^b
	12.5 (±27.1)	12.3 (±19.6)	5.5 (±25.0)	0.480	0.224	0.290	0.285	0.975
		*Willingness to Exercise*		Overall^a	AF1 + AF2 vs PBO	AF1 vs PBO	AF2 vs PBO	AF1 vs AF2
Overall^a				0.442	0.204	0.171	0.412	0.748
0	74.6 (±21.2)	73.5 (±23.8)	69.2 (±26.8)
14	74.3 (±17.5)	76.0 (±20.4)	71.0 (±23.6)		0.687	0.941	0.577	0.553
42	79.4 (±16.0)	77.3 (±26.6)	68.4 (±27.5)		0.129	0.112	0.289	0.766
84	82.7 (±16.8)	82.9 (±20.8)	71.1 (±27.9)		*0.039*	0.108	0.082	0.861
Changes to Measures of Willingness to Exercise^b
	8.1 (±21.9)	9.5 (±19.6)	2.0 (±27.0)	0.434	0.203	0.331	0.215	0.809

^aOverall p value using mean changes over time amoung the listed group/s using a Repeated Measures ANCOVA
^bThis was determined using Post Score Subtracted from Day O
Values Presented as Mean ± Standard Deviation
Values determined to be significant (p = <0.05) indicated

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