From: Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives?
Bioactive | Highest concentration found in vivo | Highest non-cytotoxic concentration observed in vitro (24Â h exposure) | Highest non-cytotoxic concentration observed in vitro (48Â h exposure) |
---|---|---|---|
DHA | 80 μM | 60 μM | |
PRO | 10 μM (systemic circulation) [19,20,21,22]; ≈200 μM (portal circulation) [23] | 70 μM | 70 μM |
C3G | 140Â nM | 140Â nM | |
PCA | 20 μM | 20 μM |