Test substance | Dose (mg/kg/day) | Parasitemia (%) | Inhibition (%) | Mean survival time (Days) | Weight on Day0 (g) | Weight on Day4 (g) | Change (%) | PCV on Day 0 (%) | PCV on Day 4 (%) | Reduction (%) |
---|---|---|---|---|---|---|---|---|---|---|
Methanol extract | 200 | 52.27 ± 1.93 0.018* | 10.57 | 10 ± 2.00 0.07NS | 31.42 ± 1.53 | 30.75 ± 1.06 0.001* | 2.13 | 45.21 ± 2.00 | 44.18 ± 1.90 0.04* | 1.86 |
400 | 44.62 ± 1.34 0.0008* | 23.66 | 12 ± 1.34 0.04* | 32.12 ± 0.85 | 32.53 ± 0.69 0.003* | −1.27 | 45.43. ± 1.65 | 45.12 ± 5.01 0.02* | 0.55 | |
600 | 24.56 ± 3.69 0.0043* | 57.98 | 15 ± 1.00 0.009* | 30.31 ± 1.66 | 31.36 ± 0.79 0.004* | −3.46 | 44.82 ± 1.23 | 44.45 ± 0.73 0.03* | 0.67 | |
800 | 15.94 ± 1.35 0.0000* | 72.73 | 20 ± 2.55 0.0002* | 31.09 ± 2.11 | 32.02 ± 0.84 0.002* | −2.99 | 46.05 ± 2.11 | 46.84 ± 1.12 0.003* | −1.40 | |
1000 | 7.32 ± 0.78 0.0000* | 87.47 | 25 ± 0.00 0.0001* | 32.00 ± 1.73 | 31.21 ± 1.63 0.001* | 2.46 | 46.36 ± 0.56 | 45.73 ± 1.56 0.0083* | −0.79 | |
Vehicle (−) | 1 ml | 58.45 ± 1.26 | – | 9 ± 1.85 | 31.63 ± 1.00 | 27.27 ± 0.89 | 13.78 | 44.72 ± 1.31 | 43.49 ± 1.82 | 2.25 |
Chloroquine (+) | 5 | 00 ± 00 | 100 | 29 ± 1.38 | 31.43 ± 2.09 | 31.58 ± 1.32 | −0.47 | 44.31 ± 1.06 | 46.45 ± 2.21 | −3.94 |