RETRACTED ARTICLE: Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA)

Table 7 Parasitemia, inhibition, survival time, body weight and packed cell volume in repository test after administration of methanolic bark extract of Pongamia pinnata against Plasmodium berghei infected BALB/c experimental mice

Test substance	Dose (mg/kg/day)	Parasitemia (%)	Inhibition (%)	Mean survival time (Days)	Weight on Day0 (g)	Weight on Day4 (g)	Change (%)	PCV on Day 0 (%)	PCV on Day 4 (%)	Reduction (%)
Methanol extract	200	52.27 ± 1.93 0.018*	10.57	10 ± 2.00 0.07^NS	31.42 ± 1.53	30.75 ± 1.06 0.001*	2.13	45.21 ± 2.00	44.18 ± 1.90 0.04*	1.86
	400	44.62 ± 1.34 0.0008*	23.66	12 ± 1.34 0.04*	32.12 ± 0.85	32.53 ± 0.69 0.003*	−1.27	45.43. ± 1.65	45.12 ± 5.01 0.02*	0.55
	600	24.56 ± 3.69 0.0043*	57.98	15 ± 1.00 0.009*	30.31 ± 1.66	31.36 ± 0.79 0.004*	−3.46	44.82 ± 1.23	44.45 ± 0.73 0.03*	0.67
	800	15.94 ± 1.35 0.0000*	72.73	20 ± 2.55 0.0002*	31.09 ± 2.11	32.02 ± 0.84 0.002*	−2.99	46.05 ± 2.11	46.84 ± 1.12 0.003*	−1.40
	1000	7.32 ± 0.78 0.0000*	87.47	25 ± 0.00 0.0001*	32.00 ± 1.73	31.21 ± 1.63 0.001*	2.46	46.36 ± 0.56	45.73 ± 1.56 0.0083*	−0.79
Vehicle (−)	1 ml	58.45 ± 1.26	–	9 ± 1.85	31.63 ± 1.00	27.27 ± 0.89	13.78	44.72 ± 1.31	43.49 ± 1.82	2.25
Chloroquine (+)	5	00 ± 00	100	29 ± 1.38	31.43 ± 2.09	31.58 ± 1.32	−0.47	44.31 ± 1.06	46.45 ± 2.21	−3.94

The values are represented as mean of 3 values ± standard deviation and significant at *P < 0.05 (compared with negative control), NS- not significant, (−) Negative control, (+) Positive control

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