Test substance | Dose (mg/kg/day) | Parasitemia (%) | Inhibition (%) | Mean survival time (Days) | Weight on Day0 (g) | Weight on Day4 (g) | Change (%) | PCV on Day 0 (%) | PCV on Day 4 (%) | Reduction (%) |
---|---|---|---|---|---|---|---|---|---|---|
Methanol extract | 200 | 38.29 ± 1.79 0.012* | 14.59 | 10 ± 2.00 0.50NS | 30.62 ± 1.22 | 30.13 ± 0.97 0.004* | 1.63 | 42.16 ± 2.33 | 42.42 ± 1.15 0.018* | −0.49 |
400 | 33.53 ± 0.43 0.0000* | 25.17 | 13 ± 1.00 0.0011* | 30.31 ± 2.33 | 31.08 ± 0.48 0.001* | 3.23 | 42.42 ± 1.05 | 42.64 ± 0.28 0.013* | −0.43 | |
600 | 28.35 ± 1.81 0.0021* | 36.71 | 17 ± 2.65 0.025* | 30.51 ± 1.85 | 30.63 ± 0.79 0.003* | 6.16 | 43.24 ± 1.65 | 44.02 ± 0.58 0.0022* | −1.46 | |
800 | 15.14 ± 1.06 0.0002* | 66.25 | 22 ± 2.00 0.0057* | 30.12 ± 1.48 | 30.72 ± 0.65 0.022* | −1.99 | 42.13 ± 2.03 | 43.36 ± 1.07 0.0084* | −2.35 | |
1000 | 07.24 ± 1.00 0.001* | 83.84 | 26 ± 2.00 0.0032* | 30.00 ± 3.21 | 31.35 ± 1.08 0.0004* | −4.53 | 43.63 ± 1.44 | 44.12 ± 2.59 0.037* | −0.91 | |
Vehicle (−) | 1 ml | 44.81 ± 1.52 | – | 10 ± 1.00 | 30.23 ± 2.41 | 28.27 ± 2.56 | 6.48 | 43.00 ± 1.00 | 38.72 ± 1.87 | 8.07 |
Chloroquine (+) | 5 | 0.00 ± 0.00 | 100 | 30 ± 0.00 | 30.24 ± 1.00 | 31.18 ± 1.23 | −3.10 | 41.83 ± 2.46 | 44.21 ± 2.12 | −4.59 |