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Table 6 Parasitemia, inhibition, survival time, body weight and packed cell volume in 4-day suppressive test after administration of methanolic bark extract of Pongamia pinnata against Plasmodium berghei infected BALB/c experimental mice

From: RETRACTED ARTICLE: Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA)

Test substance

Dose

(mg/kg/day)

Parasitemia

(%)

Inhibition

(%)

Mean survival time (Days)

Weight on Day0 (g)

Weight on Day4 (g)

Change

(%)

PCV on Day 0

(%)

PCV on Day 4

(%)

Reduction

(%)

Methanol extract

200

38.29 ± 1.79

0.012*

14.59

10 ± 2.00

0.50NS

30.62 ± 1.22

30.13 ± 0.97

0.004*

1.63

42.16 ± 2.33

42.42 ± 1.15

0.018*

−0.49

400

33.53 ± 0.43

0.0000*

25.17

13 ± 1.00

0.0011*

30.31 ± 2.33

31.08 ± 0.48

0.001*

3.23

42.42 ± 1.05

42.64 ± 0.28

0.013*

−0.43

600

28.35 ± 1.81

0.0021*

36.71

17 ± 2.65

0.025*

30.51 ± 1.85

30.63 ± 0.79

0.003*

6.16

43.24 ± 1.65

44.02 ± 0.58

0.0022*

−1.46

800

15.14 ± 1.06

0.0002*

66.25

22 ± 2.00

0.0057*

30.12 ± 1.48

30.72 ± 0.65

0.022*

−1.99

42.13 ± 2.03

43.36 ± 1.07

0.0084*

−2.35

1000

07.24 ± 1.00

0.001*

83.84

26 ± 2.00

0.0032*

30.00 ± 3.21

31.35 ± 1.08

0.0004*

−4.53

43.63 ± 1.44

44.12 ± 2.59

0.037*

−0.91

Vehicle (−)

1 ml

44.81 ± 1.52

–

10 ± 1.00

30.23 ± 2.41

28.27 ± 2.56

6.48

43.00 ± 1.00

38.72 ± 1.87

8.07

Chloroquine (+)

5

0.00 ± 0.00

100

30 ± 0.00

30.24 ± 1.00

31.18 ± 1.23

−3.10

41.83 ± 2.46

44.21 ± 2.12

−4.59

  1. The values are represented as mean of 3 values ± standard deviation and significant at *P < 0.05 (compared with negative control), NS- not significant, (−) Negative control, (+) Positive control