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Table 4 Cytotoxicity results of T cordifolia on HeLa cell line. Cytotoxicity results of T cordifolia by SRB assay on HeLa (Human cervical carcinoma)

From: Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd)

S.No Concentration (μg/mL) % Cell Death
TCE TCP TCD TCB TCA Doxorubicin
1 0.01 44.17 ± 0.38**
2 0.1 47.40 ± 0.17**
3 1 69.53 ± 0.02**
4 10 83.45 ± 0.18**
5 25 44.58 ± 0.19* 27.04 ± 0.95* 58.01 ± 0.11** 4.42 ± 3.68 10.64 ± 4.20
6 50 55.92 ± 0.71* 49.62 ± 0.35 59.46 ± 0.04** 27.50 ± 0.18 19.70 ± 2.62
7 100 69.84 ± 0.24** 58.60 ± 0.17* 76.68 ± 0.21** 42.10 ± 3.02* 33.42 ± 4.00
8 200 82.50 ± 0.83** 75.47 ± 0.12** 83.72 ± 0.19** 68.21 ± 2.45* 80.02 ± 0.38**
9 IC50 87.93 ± 0.85b 139.54 ± 1.54c 48.91 ± 0.33a,b 283.91 ± 2.93 377.39 ± 1.09 1.85 ± 0.02a
  1. Results were expressed as Mean ± SEM (n = 3) and analysed using one-way ANOVA followed by Tukey’s post hoc test of significance [where different alphabets denote significant difference (p < 0.05)]. Statistical comparison between the mean % viability of each extract and its negative control was performed using one-way ANOVA followed by Dunnett’s post hoc test of significance wherein *p < 0.05 and **p < 0.01 were considered to be statistically significant and very statistically significant compared to negative control. T cordifolia extracts were tested at concentrations of 200, 100, 50, 25 μg/mL and Doxorubicin was tested at concentrations of 0.01, 0.1, 1 and 10 μg/mL