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Table 3 Cytotoxicity results of T cordifolia on HeLa cell line. Cytotoxicity results of T cordifolia by MTT assay on HeLa (Human cervical carcinoma)

From: Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd)

S.No Concentration (μg/mL) % Cell Death
TCE TCP TCD TCB TCA Doxorubicin
1 0.01 – – – – – 39.81 ± 1.06**
2 0.1 – – – – – 48.24 ± 0.27**
3 1 – – – – – 68.43 ± 1.02**
4 10 – – – – – 82.54 ± 0.92**
5 25 39.92 ± 0.36* 29.24 ± 0.64 55.02 ± 0.68** 3.63 ± 1.54 13.47 ± 1.88 –
6 50 56.06 ± 0.73** 53.34 ± 0.48** 55.95 ± 0.43** 29.79 ± 1.79 25.84 ± 1.51 –
7 100 66.76 ± 0.51** 66.00 ± 1.12* 73.90 ± 0.59** 40.95 ± 0.69* 28.58 ± 1.98 –
8 200 80.97 ± 1.71** 77.30 ± 0.33* 81.60 ± 0.28** 76.54 ± 0.58* 84.02 ± 0.46** –
9 IC50 101.26 ± 1.42b 131.94 ± 1.23c 54.23 ± 0.94a 276.03 ± 2.00 366.05 ± 1.74 1.89 ± 0.02a
  1. Results were expressed as Mean ± SEM (n = 3) and analysed using one-way ANOVA followed by Tukey’s post hoc test of significance [where different alphabets denote significant difference (p < 0.05)]. Statistical comparison between the mean % viability of each extract and its negative control was performed using one-way ANOVA followed by Dunnett’s post hoc test of significance wherein *p < 0.05 and **p < 0.01 were considered to be statistically significant and very statistically significant compared to negative control. T cordifolia extracts were tested at concentrations of 200, 100, 50, 25 μg/mL and Doxorubicin was tested at concentrations of 0.01, 0.1, 1 and 10 μg/mL
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