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A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial

BMC Complementary and Alternative MedicineBMC series – open, inclusive and trusted201717:441

Received: 10 May 2017

Accepted: 24 August 2017

Published: 4 September 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
10 May 2017 Submitted Original manuscript
22 Jun 2017 Reviewed Reviewer Report - Gordon Howarth
3 Jul 2017 Reviewed Reviewer Report - Gerard Mullin
19 Jul 2017 Author responded Author comments - Iris Pinheiro
Resubmission - Version 2
19 Jul 2017 Submitted Manuscript version 2
19 Aug 2017 Reviewed Reviewer Report - Gerard Mullin
Resubmission - Version 3
Submitted Manuscript version 3
24 Aug 2017 Editorially accepted
4 Sep 2017 Article published 10.1186/s12906-017-1948-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

ProDigest, Ghent, Belgium
Embria Health Sciences, Ankeny, USA
Center of Microbial Ecology and Technology (CMET), University of Ghent, Ghent, Belgium
Department of Methodology and Statistics, Faculty of Health Medicine and Life Sciences, University of Maastricht, Maastricht, The Netherlands