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Table 3 Effect of ethanolic extract of E. hirta whole plant on excision wound in alloxan induced diabetic rats

From: Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats

Group/

Post wounding days

Wound area (cm2)

% of wound contraction at the end of the study

1st day

4th day

8th day

12th day

16th day

 

Group I

N/A

N/A

N/A

N/A

N/A

N/A

Group II

4.90 ± 1.13

4. 90 ± 1.20

4.85 ± 0.88

4.72 ± 0.89

4.60 ± 0.93

6.12

Group III

4.90 ± 1.11

4.83 ± 1.05†

4.58 ± 1.17†

3.76 ± 0.59†

3.14 ± 0.36†

35.92

Group IV

4.90 ± 1.03

4.70 ± 0.91†

4.50 ± 0.86†

3.23 ± 0.65†

2.71 ± 0.40*

44.69

Group V

4.90 ± 1.10

4.58 ± 1.07†

4.16 ± 0.88†

2.48 ± 0.33*

1.89 ± 0.35**

61.42

Group VI

4.90 ± 1.12

4.51 ± 1.01†

4.35 ± 0.76†

3.26 ± 0.33†

2.95 ± 0.54*

39.79

Group VII

4.90 ± 1.16

4.83 ± 1.21†

4.55 ± 0.73†

3.92 ± 0.58†

3.29 ± 0.37†

32.86

Group VIII

4.90 ± 0.88

4.75 ± 1.03†

4.47 ± 0.68†

3.41 ± 0.56†

3.12 ± 0.49†

36.32

  1. Each value is Mean ± S.E.M (n = 3). (*) indicates statistically significant difference from the diabetic wound control using ANOVA, followed by Dunnett’s multiple comparison test (** p < 0.01). (†) indicates statistically no significant difference from the diabetic wound control using ANOVA, followed by Dunnett’s multiple comparison test (p > 0.05). Group I = normal control, Group II = Diabetic wound control, Group III = Diabetic wound control +100 mg ethanolic extract of E. hirta, Group IV = Diabetic wound control +200 mg ethanolic extract of E. hirta, Group V = Diabetic wound control +400 mg ethanolic extract of E. hirta, Group VI = Diabetic wound control +5% Povidone iodine, Group VII = Diabetic wound control +5% ethanolic extract of E. hirta, Group VIII = Diabetic wound control +10% ethanolic extract of E. hirta