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Table 1 Modulation of antibiotic resistance in Pseudomonas aeruginosa by conessine

From: Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa

Bacterial strain

Antibiotic

Antibiotic Minimum inhibitory concentration (mg/L) with

Fractional inhibitory concentration indexb

No EPIa

Conessine (20 mg/L)

PAβN (25 mg/L)

Conessine

PAβN

K767 (PAO1)

Cefotaxime

8

1

4

0.63

0.52

 

Erythromycin

128

16

64

0.63

0.52

 

Levofloxacin

0.25

0.03

0.03

0.63

0.15

 

Novobiocin

1024

128

128

0.63

0.15

 

Rifampicin

16

2

2

0.63

0.15

 

Tetracycline

8

1

4

0.63

0.52

K1455 (PAO1-nalB)

Cefotaxime

64

8

64

0.63

1.02

 

Erythromycin

256

32

64

0.63

0.27

 

Levofloxacin

2

0.25

0.25

0.63

0.15

 

Novobiocin

>2048

256

256

0.63

0.15

 

Rifampicin

16

2

2

0.63

0.15

 

Tetracycline

64

8

64

0.63

1.02

K1523 (PAO1-∆mexB)

Cefotaxime

1

0.13

0.13

0.63

0.17

 

Erythromycin

128

16

64

0.63

0.55

 

Levofloxacin

0.06

0.01

0.01

0.63

0.17

 

Novobiocin

64

64

64

1.50

1.05

 

Rifampicin

16

2

2

0.63

0.17

 

Tetracycline

8

1

2

0.63

0.30

  1. A reduction of at least 4-fold is indicated in bold
  2. aEPI, Efflux pump inhibitor
  3. bSynergy, <1; additivity, =1; antagonism >1