Skip to main content
Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice

Fig. 4

[6]-Gingerol activates cAMP/PKA/CREB pathway in pancreatic islets. Following an oral glucose load, pancreatic islets were isolated from Leprdb/db mice treated with [6]-Gingerol treated (4 weeks, 200 mg/kg/day orally) with or without different pharmacological modulators of GLP-1. a cAMP content, b Pka expression, c PKA activity, d Creb expression, and e pCREB (S133) levels were measured in the islets isolated from different treatment groups (n = 8 mice for each group in a-e). f Plasma Insulin level following acute glucose administration (2 g/kg, oral) in [6]-Gingerol treated (4 weeks, 200 mg/kg/day orally) mice with/without 7 days’ treatment of H-89 (0.2 mg/100 g i.p.). H-89 is a selective inhibitor of cAMP-dependent protein kinase (PKA). Values are presented as Mean±SD (n = 8 mice for each group in f). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. not significant (One-way ANOVA, pair-wise comparison, Bonferroni correction)

Back to article page