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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice

Fig. 3

GLP-1 mediates the glucose-induced insulin secretion activity of [6]-Gingerol. Leprdb/db mice treated for 4 weeks with daily 200 mg/kg [6]-Gingerol were fasted overnight and plasma a GLP-1 and b Insulin levels were measured after 1 h of an acute oral glucose challenge (2 g/kg). Different groups of the vehicle and 6]-Gingerol treated mice were additionally treated with pharmacological modulators of GLP-1: Extendin (9-39) and Saxagliptin. Exendin (9–39), a GLP-1 receptor antagonist; dose 300 pmol/kg/min; administered through a femoral vein catheter continuously for 30mins while the subjects were kept under sodium pentobarbital anesthesia. Saxagliptin, an inhibitor of dipeptidyl peptidase- 4; dose 10 μmol/l; administered orally 4 h before the glucose load. Values are presented as Mean±SD (n = 8 mice for each group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s. not significant (One-way ANOVA, pair-wise comparison, Bonferroni correction)

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BMC Complementary Medicine and Therapies

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