Fig. 4

Effects of SNE on the frequency (A) and duration(C) of stereotypy in mice. Graphs A and C are the time-course effects of varying doses of SNE recorded over 180 min. Graphs B and D indicate the total frequency and duration of stereotypy behaviour (calculated as AUCs from the time-course graphs). Data are mean ± SEM (n = 5). *P ≤ 0.05, ** P ≤ 0.01, ***P ≤ 0.001 compared with vehicle group (Two-way ANOVA followed by a Bonferroni’s posthoc test). ^† P ≤ 0.05, ^†† P ≤ 0.01, ^††† P ≤ 0.001 compared with vehicle group (one-way ANOVA followed by a Dunnett’s multiple comparison post hoc test)