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Table 4 Body weight and relative organ weights after 21 days of treatment with 7-methoxycoumarin (MC) and F. umbellata aqueous extract on postmenopausal-rat model

From: Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study

Organs (mg/kg)

Ovariectomized rats

SHAM

OVX

E2V

FU 50

FU 200

MC

Body weight (g)

 Initial

166.11 ± 8.74

196.21 ± 5.96

223.4 ± 11.16

221.4 ± 9.99

227.2 ± 6.37

217.4 ± 9.63

 Final

170.12 ± 9.07

228.25 ± 9.87#

227.8 ± 10.38

213.1 ± 12.30

232.2 ± 4.88

231.2 ± 10.30

Abdominal fat

214,781.26 ± 7565.50

24,764.24 ± 3112.63

126,762.1 ± 12,637.27**

171,691.87 ± 7204.37

204,538.59 ± 10,865.97*

159,774.48 ± 6658.63

Liver

270,365.48 ± 8253.71

264,972.88 ± 3943.36

283,443.82 ± 7685.54

262,571.47 ± 9392.70

238,002.87 ± 6425.51

235,675.89 ± 5742.40

Lungs

118,498.50 ± 15,472.69

94,800.44 ± 6201.97

72,416.58 ± 7256.60

95,271.092 ± 15,943.46

83,943.78 ± 1247.63

89,067.78 ± 6817.63

Kidneys

64,222.43 ± 4210.62

52,320.42 ± 2500.44

55,721.72 ± 2277.40

59,531.12 ± 3155.58

56,560.25 ± 1821.70

56,512.05 ± 2116.07

Femur

38,986.17 ± 3280.98

34,515.25 ± 916.01

37,866.95 ± 2081.32

45,917.25 ± 6570.63

52,231.77 ± 2007.19**

33,434.41 ± 2449.05

Dried Femur

18,786.86 ± 22.23

16,838.91 ± 1007.69

17,670.96 ± 341.22

21,179.00 ± 1341.27 *

24,415.28 ± 852.49 **

16,766.41 ± 902.75

Tibia

22,684.56 ± 1637.99

17,455.86 ± 1167.04

19,311.75 ± 831.75

21,544.21 ± 917.37

30,168.61 ± 1688.17 **

21,109.35 ± 2933.98

Adrenergic

3467.83 ± 199.62

2561.80 ± 289.87

2337.06 ± 237.95

2834.97 ± 192.60

2693.05 ± 116.49

3066.73 ± 211.96

  1. SHAM = Sham operated rats treated with vehicle as normal control; OVX = Ovariectomized rats treated with vehicle as negative control; E2V = Ovariectomized rats treated with estradiol valerate at the dose of 1 mg/kg BW; FU 50 and 200 = Ovariectomized rats treated with F. umbellata aqueous extract at the doses of 50 and 200 mg/kg BW, respectively; MC = Ovariectomized rats treated with 7-methoxycoumarin at the dose of 1 mg/kg BW. ## p < 0.01 as compared to SHAM group. *p < 0.05 **p < 0.01 as compared to OVX group; #p < 0.05 Body weight at the end of treatment compared to itself at the beginning of the treatment