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Table 3 Effects of 7-methoxycoumarin (MC) and F. umbellata aqueous extract on estrogen target organs and lipids profile on postmenopausal-rat model after 21 days treatment

From: Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study

  

Ovariectomized rats

Items

SHAM

OVX

E2V

FU 50

FU 200

MC

Estrogen target organs

 Uterine wet weight (mg/kg)

1921.36±185.26

356.9±19.05###

1288.42±136.9***

546.12±44.24

349.69±7.69

409.83±15.81

 Uterine epithelial height (μm)

6.71±0.36

3.06±0.16###

5.27±0.15***

3.6±0.37

3.84±0.18

3.39±0.20

 Vaginal epithelial height (μm)

19.06±0.11

2.54±0.56###

14.25±0.55***

6.24±0.20**

7.86±0.01**

8.56±1.39***

Lipids profile

 Total cholesterol level (mg/dL)

67.92±6.27

93.9±2.29##

56.98±11.27*

83.01±10.27

56.53±4.99*

79.24±11.67

 Triglycerides levels (mg/dL)

47.96±3.75

62.96±7.35#

44.66±2.02*

63.01±6.46

49.48±1.67

56.08±4.26

 HDL-Cholesterol level (mg/dL)

46.62±0.91

44.91±0.34#

45.94±0.54*

45.1±0.38

45.60±0.66*

45.33±0.44

 Atherogenic risk

1.28±0.20

1.63±0.15#

1.19±0.15*

1.84±0.22

1.19±0.21 *

1.69±0.22

  1. SHAM = Sham operated rats treated with vehicle as normal control; OVX = Ovariectomized rats treated with vehicle as negative control; E2V = Ovariectomized rats treated with estradiol valerate at the dose of 1 mg/kg BW; FU 50 and 200 = Ovariectomized rats treated with F. umbellata aqueous extract at the doses of 50 and 200 mg/kg BW, respectively; MC = Ovariectomized rats treated with 7-methoxycoumarin at the dose of 1 mg/kg BW. # p <0.05, ## p < 0.01, ### p <0.001 as compared to SHAM group. *p <0.05, **p < 0.01, ***p <0.001 as compared to OVX group