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Table 2 Cytotoxicity and protein kinase inhibition of different solvent extracts of Q. dilatata

From: Polarity directed optimization of phytochemical and in vitro biological potential of an indigenous folklore: Quercus dilatata Lindl. ex Royle

Samples

Brine shrimp cytotoxicity (μg/ml)

THP-1 cytotoxicity (μg/ml)

Hep G2 cytotoxicity (μg/ml)

Isolated lymphocytes

Protein kinase inhibition (μg/disc)

 

% mortality

LC50

% inhibition

IC50

% inhibition

IC50

% inhibition

IC50

Diameter (mm) at 100 μg/disc

MIC

 

200

 

20

 

20

 

20

 

Clear zone

Bald zone

 

NH

33.6 ± 2.5a

>200

22.32 ± 2.41c

> 20

46.73 ± 0.85 a

>20

8.76 ± 1.12

>20

--

7 ± 0.15c

--

C

80.00 ± 0.49b

96.45 ± 0.98

14.24 ± 1.77a

> 20

43.20 ± 1.56 a

>20

10.43 ± 2.56

>20

--

25 ± 0.2a

12.5

A

42.5 ± 0.94b

>200

82.43 ± 1.68

3.88 ± 0.53

41.20 ± 1.56 a

>20

14.43 ± 1.21

>20

--

8 ± 0.47

--

EtA

80.0 ± 0.47a

77.7 ± 1.14

38.42 ± 2.13b

> 20

38.03 ± 2.28 b

>20

12.43 ± 1.43

>20

--

7 ± 0.39c

--

Et

50.0 ± 1.25c

>200

47.25 ± 2.99

> 20

41.32 a ± 2.56 b

>20

15.21 ± 1.22

>20

--

27 ± 0.47a

12.5

CE

91.5 ± 0.94 c

49.62 ± 0.22

19.56 ± 3.22

> 20

9.72 ± 0.87

>20

13.87 ± 2.12

>20

--

9 ± 0.52b

--

CM

100.0 ± 1.70a

34.54 ± 0.16

21.56 ± 2.87

> 20

28.27 ± 0.85

>20

6.65 ± 1.54

>20

--

7 ± 0.21

--

EEt

100.0 ± 0.94

81.4 ± 0.17

43.12 ± 3.18

> 20

42.79 ± 0.76 a

>20

5.86 ± 1.01

>20

--

9 ± 0.15

--

MEt

80.30 ± 2.36

69.9 ± 0.18

71.5 ± 4.11

5.59 ± 0.25

23.51 ± 1.54

>20

14.76 ± 2.22

>20

--

10 ± 0.41b

--

E

100.0 ± 0.94a

86.62 ± 1.35

82.52 ± 1.45b

4.95 ± 0.53

42.30 ± 1.12 a

>20

12.87 ± 1.12

>20

--

26 ± 0.42a

12.5

DA

82.40 ± 1.25

49.1 ± 1.18

62.85 ± 2.45

9.24 ± 0.53

26.21 ± 1.21

>20

16.34 ± 4.45

>20

--

8 ± 0.35

--

M

91.50 ± 1.70

71.0 ± 0.74

22.53 ± 0.83a

> 20

45.50 ± 1.43 a

>20

18.45 ± 3.98

>20

--

28 ± 0.35a

12.5

DM

80.50 ± 1.70

92.3 ± 1.70

42.54 ± 2.45

> 20

9.64 ± 0.76 c

>20

22.54 ± 5.16

>20

--

8 ± 0.35

--

D

90.0 ± 1.70

78.4 ± 1.70

48.54 ± 0.83a

> 20

--

>20

12.11 ± 1.15

>20

--

9 ± 0.55

--

Doxorubicin

100

5.93

  

98 ± 0.18

5.1

     

5-Florouracil

  

100

5

       

Vincristine

  

100

8.1

  

73.45 ± 1.56

6.66 ± 0.22

   

Surfactin

         

30 ± 1.02

 

DMSO

  

--

     

--

--

 

1% DMSO in PBS/sea water

--

 

--

 

--

 

--

--

   
  1. Values are presented as mean ± standard deviation of triplicate analysis. --: no activity. a-c means difference is highly significant, slightly significant, significant at p < 0.05