Table 7 Human equivalent dose calculation based on body surface areaa
From: Acute and sub-acute toxicity study of a Pakistani polyherbal formulation
Species | References body weight (kg) | References body range (kg) | Body surface area (m2) | To convert dose in mg/kg to dose in mg/m2, multiply by Km | To convert animal dose in mg/kg, either | |
|---|---|---|---|---|---|---|
Divide animal dose by | Divide animal dose by | |||||
Human | 60 | - | 1.62 | 37 | - | - |
Mouse | 0.02 | 0.011-0.3034 | 0.007 | 3 | 12.3 | 0.081 |
Hamster | 0.08 | 0.047-0.157 | 0.016 | 5 | 7.4 | 0.135 |
Rat | 0.15 | 0.08-0.27 | 0.025 | 6 | 6.2 | 0.162 |
Ferret | 0.20 | 0.16-0.54 | 0.043 | 7 | 5.3 | 0.189 |
Guinea pig | 0.40 | 0.208-0.700 | 0.05 | 8 | 4.6 | 0.216 |
Rabbit | 1.8 | 0.90-3.0 | 0.15 | 12 | 3.1 | 0.324 |
Dog | 10 | 5-17 | 0.50 | 20 | 1.8 | 0.541 |
Monkey (rhesus) | 3 | 1.4-4.9 | 0.25 | 12 | 3.1 | 0.324 |
Marmoset | 0.35 | 0.14-0.72 | 0.06 | 6 | 6.2 | 0.162 |
Squirrel monkey | 0.60 | 0.29-0.97 | 0.09 | 7 | 5.3 | 0.189 |
Baboon | 12 | 7-23 | 0.60 | 20 | 1.8 | 0.541 |
Macro pig | 20 | 10-23 | 0.74 | 27 | 1.4 | 0.730 |
Mini pig | 40 | 25.64 | 1.14 | 35 | 1.1 | 0.946 |