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Table 4 Cytotoxic activity of saponins fractions (100 μg/ml) from Z. armatum using NRU assay

From: Cytotoxic activity of extracts and crude saponins from Zanthoxylum armatum DC. against human breast (MCF-7, MDA-MB-468) and colorectal (Caco-2) cancer cell lines

Fractions (100 μg/ml)

Percentage growth inhibition of cancer cells (Mean ± Std. Dev.)

MCF-7 cells

MDA MB-468 cells

Caco-2 cells

Vehicle Control

Zf.Sa

81.67*** (±4.15)

93.81*** (±2.32)

53.16*** (±3.31)

−0.19 (±2.68)

Zl.Sa

48.58 (±7.36)

71.19 (±2.76)

45.96 (±10.67)

4.23 (±7.80)

Zb.Sa

7.77 (±4.83)

95.25***(±4.35)

66.43(±3.24)

2.92(±3.20)

Actinomycin-D (4 μM)

91.84*** (±3.73)

93.94*** (±5.02)

65.97** (±4.83)

1.67 (±1.06)

  1. In the table statistically (Dunnett’s multiple comparison test)* = Significant (P < 0.05), ** = Highly significant (P < 0.01), *** = Very highly significant (P < 0.001)