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Table 2 Cytotoxic activity of saponins fractions (200 μg/ml) from Z. armatum using MTT assay

From: Cytotoxic activity of extracts and crude saponins from Zanthoxylum armatum DC. against human breast (MCF-7, MDA-MB-468) and colorectal (Caco-2) cancer cell lines

Fractions (200 μg/ml)

Percentage growth inhibition of cancer cells (Mean ± Std. Dev.)

MCF-7 cells

MDA MB-468 cells

Caco-2 cells

Vehicle Control

Zf.Sa

79.69*** (±7.45)

95.00*** (±2.64)

75.88*** (±8.41)

3.17 (±5.67)

Zl.Sa

49.08** (±5.21)

85.33*** (±3.41)

68.62** (±2.48)

3.43 (±6.80)

Zb.Sa

9.43 (±3.82)

94.59*** (±3.00)

61.82** (±4.07)

0.20 (±2.34)

Actinomycin-D (4 μM)

62.04** (±1.43)

62.87** (±5.28)

65.40** (±4.29)

1.10 (±1.13)

  1. In the table statistically (Dunnett’s multiple comparison test) * = Significant (P < 0.05), ** = Highly significant (P < 0.01), *** = Very highly significant (P < 0.001)