Table 1 Cytotoxic activity of crude extract of Z. armatum using MTT assay with apparent IC50 about 200 μg/ml
Conc. (μg/ml) | Z. armatum fruit extract (Zf) | Z. armatum leaves extract (Zl) | Z. armatum bark extract (Zb) | ||||||
|---|---|---|---|---|---|---|---|---|---|
MCF-7 cells | MDA MB-468 cells | Caco-2 cells | MCF-7 cells | MDA MB-468 cells | Caco-2 cells | MCF-7 cells | MDA MB-468 cells | Caco-2 cells | |
10 | 21.58* ±3.2 | 9.8 ± 3.6 | 15.96* ±6.8 | 3.56 ± 1.8 | 0.87 ± 0.4 | 3.83 ± 2.3 | 4.25 ± 3.8 | 16.51 ± 4.6 | 5.21 ± 1.4 |
25 | 37.50** ± 4.1 | 12.72* ±3.0 | 27.97* ±2.1 | 2.79 ± 1.0 | 2.50 ± 0.5 | 4.10 ± 2.1 | 6.08 ± 2.0 | 27.54* ±3.2 | 16.33 ± 1.2 |
50 | 35.45** ± 8.6 | 22.78* ±1.9 | 49.25 ** ± 5.0 | 11.22 ± 2.6 | 4.11 ± 0.9 | 8.60 ± 4.3 | 7.46 ± 5.5 | 42.25** ±3.4 | 12.63 ± 3.2 |
100 | 35.22** ± 5.1 | 38.90** ± 3.9 | 53.93*** ±4.0 | 26.14* ±5.0 | 6.23 ± 1.4 | 14.21 ± 2.0 | 11.18 ± 4.0 | 46.22** ±4.6 | 20.52* ±1.4 |
200 | 58.28*** ± 4.8 | 57.26*** ± 4.4 | 64.95*** ±4.2 | 35.71** ±4.7 | 20.97* ±2.3 | 21.05* ± 4.4 | 17.28 ± 3.9 | 74.39*** ±2.8 | 39.38** ±4.8 |
300 | 65.74*** ± 7.8 | 69.48*** ± 4.7 | 75.60*** ±8.5 | 54.35*** ± 4.6 | 41.97** ±1.1 | 28.56* ± 2.3 | 23.06* ± 3.2 | 74.87*** ±3.9 | 62.72*** ±3.0 |
400 | 73.70*** ± 10.2 | 85.15*** ± 2.8 | 88.90*** ±5.8 | 63.77*** ± 3.2 | 99.58*** ±0.2 | 41.63** ± 4.7 | 59.21*** ±2.9 | 84.24*** ±6.4 | 63.56*** ±4.7 |
500 | 95.88*** ± 6.0 | 90.54*** ±6.8 | 94.24*** ±4.3 | 78.63*** ± 4.2 | 99.35*** ±0.5 | 50.14*** ± 3.5 | 71.15*** ±2.6 | 99.76*** ±0.7 | 68.37*** ±2.8 |
Veh. Cont. | 2.87 ± 0.6 | 4.92 ± 2.91 | −2.10 ± 0.2 | 1.10 ± 1.13 | 1.57 ± 3.6 | 1.68 ± 5.2 | 1.69 ± 4.4 | 1.67 ± 1.0 | 1.76 ± 5.1 |