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Table 5 Protective effect of B.orthobotrys on hematological profile in normal and experimental rats (n = 5, Mean ± SEM)

From: Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch

Hematological parameter

Arthritic control

Normal control

Standard (Aspirin)

Aqueous- methanolic extract

n-butanol fraction

Ethyl acetate fraction

Aqueous fraction

Hb

(g/dl)

9.36 ± 0.145

14.26 ± 0.240***

12.60 ± 0.058***

13.40 ± 0.115***

13.36 ± 0.176***

12.63 ± 0.133***

11.70 ± 0.115***

RBCs

(× 106 / μl)

4.97 ± 0.079

7.42 ± 0.266***

6.72 ± 0.133***

6.80 ± 0.038***

6.53 ± 0.104***

6.30 ± 0.038***

5.78 ± 0.059**

WBCs

(× 103 / μl)

9.43 ± 0.203

5.23 ± 0.120***

7.70 ± 0.208***

6.20 ± 0.265***

6.80 ± 0.346***

7.50 ± 0.208***

8.50 ± 0.058*

Platelets

(× 103 / μl)

1225.00 ± 105.39

311.00 ± 3.215***

732.33 ± 4.631***

394.00 ± 3.512***

492.33 ± 3.528***

591.66 ± 2.728***

692.00 ± 3.786***

ESR

(mm / 1st h)

20.33 ± 0.882

3.00 ± 0.577***

12.33 ± 1.202***

9.00 ± 0.577***

11.00 ± 0.577***

12.33 ± 0.882***

15.00 ± 0.577**

RF

(IU / ml)

48.33 ± 2.028

14.00 ± 0.00***

25.33 ± 2.333***

20.00 ± 1.155***

25.66 ± 0.882***

32.66 ± 1.453***

35.33 ± 1.764***

  1. The statistical analysis was done with one-way ANOVA followed by Dunnett’s multiple comparison test. *** = p < 0.001, ** = p < 0.01, * = p > 0.05 compared with arthritic control