Treatment groups | Increase in paw diameter (mm) | ||||
---|---|---|---|---|---|
Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | |
Arthritic control (3 ml/kg) | 8.49 ± 0.029 | 10.62 ± 0.023 | 12.56 ± 0.021 | 14.08 ± 0.020 | 16.92 ± 0.022 |
Standard Aspirin (100 mg/kg) | 4.61 ± 0.021*** (45.70) | 4.95 ± 0.023*** (53.38) | 4.07 ± 0.019*** (67.59) | 3.77 ± 0.028*** (73.22) | 3.63 ± 0.033*** (78.54) |
Aqueous-methanolic extract (50 mg/kg) | 4.76 ± 0.035*** (43.93) | 5.35 ± 0.026*** (49.62) | 4.41 ± 0.018*** (64.88) | 4.12 ± 0.021*** (70.73) | 4.09 ± 0.019*** (75.82) |
Aqueous-methanolic extract (100 mg/kg) | 4.51 ± 0.015*** (46.87) | 4.93 ± 0.023*** (53.57) | 4.10 ± 0.028*** (67.35) | 3.72 ± 0.029*** (73.57) | 3.60 ± 0.027*** (78.72) |
Aqueous-methanolic extract (150 mg/kg) | 4.28 ± 0.011*** (49.58) | 4.63 ± 0.016*** (56.40) | 3.63 ± 0.030*** (71.09) | 3.28 ± 0.023*** (76.70) | 3.03 ± 0.017*** (82.09) |
n-butanol fraction (50 mg/kg) | 4.96 ± 0.019*** (41.57) | 5.46 ± 0.020*** (48.58) | 4.85 ± 0.025*** (61.38) | 4.65 ± 0.024*** (66.97) | 4.54 ± 0.027*** (73.16) |
n-butanol fraction (100 mg/kg) | 4.68 ± 0.023*** (44.87) | 5.11 ± 0.021*** (51.88) | 4.41 ± 0.021*** (64.88) | 4.13 ± 0.021*** (70.66) | 4.02 ± 0.021*** (76.24) |
n-butanol fraction (150 mg/kg) | 4.38 ± 0.026*** (48.40) | 4.28 ± 0.020*** (59.69) | 3.68 ± 0.023*** (70.70) | 3.55 ± 0.021*** (74.78) | 3.30 ± 0.023*** (80.49) |
Ethyl acetate fraction (50 mg/kg) | 5.40 ± 0.033*** (36.39) | 5.70 ± 0.022*** (46.32) | 5.32 ± 0.030*** (57.64) | 5.00 ± 0.021*** (64.48) | 4.91 ± 0.022*** (70.98) |
Ethyl acetate fraction (100 mg/kg) | 5.25 ± 0.021*** (38.16) | 5.50 ± 0.021*** (48.21) | 4.75 ± 0.017*** (62.18) | 4.54 ± 0.022*** (67.75) | 4.48 ± 0.022*** (73.52) |
Ethyl acetate fraction (150 mg/kg) | 4.75 ± 0.020*** (44.05) | 5.05 ± 0.017*** (52.44) | 4.37 ± 0.024*** (65.20) | 4.00 ± 0.021*** (71.59) | 3.85 ± 0.022*** (77.24) |
Aqueous fraction (50 mg/kg) | 5.88 ± 0.022*** (30.74) | 6.13 ± 0.021*** (42.27) | 5.71 ± 0.024*** (54.53) | 5.37 ± 0.022*** (61.86) | 5.25 ± 0.024*** (68.97) |
Aqueous fraction (100 mg/kg) | 5.43 ± 0.024*** (36.04) | 5.96 ± 0.030*** (43.87) | 5.18 ± 0.027*** (58.75) | 4.85 ± 0.028*** (65.55) | 4.75 ± 0.027*** (71.92) |
Aqueous fraction (150 mg/kg) | 4.98 ± 0.023*** (41.34) | 5.58 ± 0.027*** (47.45) | 4.47 ± 0.024*** (64.41) | 4.25 ± 0.021*** (69.81) | 4.20 ± 0.022*** (75.17) |