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Table 5 Modulation of caspase (−8, −9, −3/7) activities and ATP levels in 72 h CLE treated THP-1 cells

From: Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

CLE (mg/ml)

Caspase-8 (RLU × 105)

Caspase-9 (RLU × 105)

Caspase-3/7 (RLU × 105)

ATP (RLU × 105)

Control

1.068 ± 0.002

6.694 ± 0.002

8.218 ± 0.002

4.552 ± 0.029

0.05

1.021 ± 0.001**

6.343 ± 0.009***

6.293 ± 0.001***

4.252 ± 0.039***

0.2

0.972 ± 0.0003***

5.442 ± 0.034***

4.954 ± 0.002***

3.852 ± 0.039***

0.4

11.246 ± 0.034***

4.271 ± 0.001***

3.596 ± 0.005***

3.013 ± 0.005***

0.8

0.286 ± 0.0001***

1.720 ± 0.001***

0.497 ± 0.001***

1.065 ± 0.011***

  1. (Values expressed as mean ± SD, ** p < 0.001, *** p < 0.0001 compared to the control)