Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC’s)

Table 2 Modulation of caspase (−8, −9, −3/7) activities and ATP levels in 24 h C_LE treated PBMC’s

C_LE (mg/ml)	Caspase-8 (RLU × 10⁵)	Caspase-9 (RLU × 10⁵)	Caspase-3/7 (RLU × 10⁵)	ATP (RLU × 10⁵)
Control	0.146 ± 0.001	0.265 ± 0.002	5.861 ± 0.028	3.486 ± 0.011
0.05	0.176 ± 0.001^***	0.293 ± 0.001^***	6.066 ± 0.032	3.168 ± 0.006^***
0.2	0.256 ± 0.003^***	0.364 ± 0.002^***	6.264 ± 0.031^**	3.074 ± 0.002^***
0.4	0.135 ± 0.001^***	0.397 ± 0.0003^***	16.407 ± 0.263^***	4.180 ± 0.013^***
0.8	0.101 ± 0.001^***	0.307 ± 0.0004^***	6.331 ± 0.007^***	0.796 ± 0.002^***

(Values expressed as mean ± SD, ^** p < 0.001, ^*** p < 0.0001 compared to the control)

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