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Table 8 Effects of doses of aqueous extract from A.cordifolia on biochemical parameters after 2 weeks of administration to rats

From: Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)

Studied Parameters Doses
0- mg/kg 0i mg/kg 58 mg/kg 116 mg/kg 232 mg/kg
Serum Creatinine (mg/ dl) 2.64 ± 0.19b 5.00 ± 0.92a 2.31 ± 0.88b 2.62 ± 1.15b 2.65 ± 0.97b
Urine Creatinine (mg/ dl) 25.35 ± 3.88a 26.88 ± 2.28a 25.85 ± 5.15a 26.38 ± 3.64a 28.09 ± 3.45a
Total Cholesterol (mg/ dl) 288.89 ± 14.43a 285.26 ± 11.47a 329.38 ± 13.53a 335.90 ± 12.31a 340.72 ± 5.16a
HDL Cholesterol (mg/dl) 58.60 ± 3.30a 51.91 ± 4.36a 65.21 ± 5.97a 63.67 ± 3.87a 62.50 ± 2.68a
Atherosclerosis Index(mg/ dl) 3.98 ± 0.86a 4.58 ± 0.55a 4.51 ± 0.12a 4.78 ± 0.74a 4.55 ± 1.07a
Triglycerides (mg/dl) 114.85 ± 7.09a 102.46 ± 10.65a 110.10 ± 7.92a 119.64 ± 6.44a 126.29 ± 5.94a
Renal protein (mg/g) 3.81 ± 0.95a 3.67 ± 1.11a 3.72 ± 1.07a 3.98 ± 1.02a 4.02 ± 0.29a
Spleen protein (mg/g) 72.73 ± 9.71a 71.82 ± 8.40a 75.55 ± 6.79a 79.64 ± 9.58a 84.36 ± 7.82a
Pulmonary protein (mg/g) 59.09 ± 3.02a 42.81 ± 2.22b 40.97 ± 4.26b 41.58 ± 4.21b 45.36 ± 3.86b
Hepatic protein (mg/g) 148.73 ± 2.70ab 127.91 ± 12.18b 134.82 ± 5.94b 141.82 ± 6.31ab 154.91 ± 13.08a
Cardiac protein (mg/g) 53.94 ± 5.08a 40.03 ± 2.57b 42.73 ± 2.49ab 46.00 ± 6.08ab 49.45 ± 4.71ab
Serum protein (mg/g) 413.36 ± 19.7a 410.57 ± 12.60a 395.39 ± 14.57b 400.02 ± 17.01b 402.91 ± 10.58b
Urine protein (mg/g) 3.64 ± 0.94a 3.24 ± 0.20ab 2.80 ± 0.14b 3.28 ± 0.21ab 3.15 ± 0.32ab
ALAT (UI/l) 30.36 ± 2.92b 39.42 ± 3.51a 34.86 ± 1.74ab 41.92 ± 2.33a 43.79 ± 2.44a
ASAT (UI/l) 55.19 ± 3.18a 51.90 ± 4.21ab 49.02 ± 3.49b 53.88 ± 4.34ab 57.11 ± 4.33a
  1. 0-: Normal control, 0i: Infected and non-treated. Tabulated values are mean ± SEM of five trials. Values of the same row with different letters are significantly different at P < 0.05