Skip to main content

Table 2 Serum biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats treated with various doses of the aqueous extract and whole formula powder of Mathurameha herbal formula

From: Hypoglycaemic activity of Mathurameha, a Thai traditional herbal formula aqueous extract, and its effect on biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats

Treatment group (N = 5)

Lipid profiles

Liver functions

Renal functions

CHOL (mg/dL)

TG (mg/dL)

ALP(U/L)

ALT(U/L)

AST(U/L)

TP(g/dL)

ALB(g/dL)

GLO(g/dL)

BUN(mg/dL)

CREA(mg/dL)

UA (mg/dL)

Normal control

96.80 ± 4.55b

93.40 ± 14.66

85.40 ± 14.71b

57.80 ± 9.73

122.40 ± 34.05

7.42 ± 0.24b

4.90 ± 0.10b

2.54 ± 0.18b

19.78 ± 1.80b

0.28 ± 0.04b

2.2 ± 0.56b

Diabetic control

119.20 ± 15.32a

138.00 ± 39.34

541.80 ± 167.86a

61.60 ± 19.59

106.60 ± 17.95

5.38 ± 0.33a

3.58 ± 0.30a

1.80 ± 0.14a

33.18 ± 5.88a

0.36 ± 0.05a

4.54 ± 2.15a

Glibenclamide 5 mg/kg

97.20 ± 23.51b

132.80 ± 32.52

388.00 ± 144.73a

52.00 ± 34.12

96.60 ± 50.28

5.00 ± 0.79a

3.56 ± 0.50a

1.42 ± 0.34a

30.76 ± 6.13a

0.28 ± 0.04b

2.48 ± 1.93b

Aqueous extract 12.5 mg/kg

125.25 ± 13.77a

197.00 ± 102.36a

289.00 ± 94.26b

62.00 ± 21.35

117.25 ± 34.51

6.98 ± 0.90b

4.78 ± 0.43b

2.25 ± 0.62

34.08 ± 8.04a

0.30 ± 0.08b

2.50 ± 0.93b

Aqueous extract 25 mg/kg

100.40 ± 5.98b

154.40 ± 43.17

315.40 ± 132.89ab

30.80 ± 14.91ab

84.40 ± 29.99

5.32 ± 0.59a

3.54 ± 0.23a

1.74 ± 0.38a

30.86 ± 5.42a

0.26 ± 0.05b

1.46 ± 0.34b

Aqueous extract 50 mg/kg

110.80 ± 21.66

168.00 ± 66.12a

384.40 ± 173.95a

43.80 ± 12.93

98.60 ± 30.78

6.04 ± 1.16a

4.02 ± 0.79a

1.98 ± 0.52a

33.82 ± 10.60a

0.26 ± 0.05b

2.34 ± 1.35b

Whole formula powder 87.5 mg/kg

112.50 ± 14.53a

181.25 ± 31.53a

413.00 ± 197.22a

41.00 ± 13.44

94.50 ± 49.68

6.10 ± 0.42a

4.20 ± 0.18ab

1.90 ± 0.34a

39.00 ± 13.26a

0.23 ± 0.05b

1.80 ± 0.80b

Whole formula powder 175 mg/kg

121.75 ± 20.85a

168.25 ± 67.37a

398.75 ± 208.32a

47.50 ± 11.73

109.25 ± 33.09

6.88 ± 1.24b

4.68 ± 0.51b

2.25 ± 0.69

37.38 ± 10.15a

0.33 ± 0.05b

2.55 ± 2.32b

Whole formula powder 350 mg/kg

119.00 ± 12.10

141.80 ± 33.49

465.80 ± 222.82a

48.60 ± 14.94

110.40 ± 25.86

5.92 ± 0.46a

4.16 ± 0.22a#

1.80 ± 0.31a

35.10 ± 4.25a

0.24 ± 0.05b

2.78 ± 1.20b

  1. Data were presented as a mean ± S.D.; CHOL total cholesterol, TG triglyceride, ALP alkaline phosphatase, ALT alanine transferase, AST aspartate transferase, TP total protein, ALB albumin, GLO globulin, BUN blood urea nitrogen, CREA creatinine, UA uric acid;
  2. aSignificant different from normal control, aSignificant different from diabetic control (p < 0.05; One-way ANOVA)