Table 4 Relative quantitative (mM) of significant discriminating metabolites of serum using Chenomx NMR Suite at week8 of treatment

386.2 ± 11.8^a

150.4 ± 13.6^d

175.8 ± 4.3^c

260.5 ± 9.7^b

171.3 ± 2.8^cd

0.91 ± 0.15^b

1.77 ± 0.17^a

1.50 ± 0.16^ab

1.15 ± 0.13^ab

1.46 ± 0.06^ab

18.55 ± 6.45^c

51.21 ± 2.63^a

44.72 ± 5.33^a

25.76 ± 3.24^bc

30.07 ± 1.61^b

0.27 ± 0.02^d

0.79 ± 0.13^a

0.54 ± 0.05^bc

0.35 ± 0.03^cd

0.61 ± 0.05^ab

0.98 ± 0.06^c

3.96 ± 1.27^a

2.63 ± 0.14^ab

1.67 ± 0.13^bc

2.78 ± 0.15^ab

0.62 ± 0.10^b

1.48 ± 0.35^a

1.21 ± 0.14^a

0.97 ± 0.23^ab

1.19 ± 0.06^a

1.13 ± 0.05^a

1.56 ± 0.10^a

1.27 ± 0.15^a

1.16 ± 0.14^a

1.32 ± 0.12^a

51.47 ± 5.0^a

27.56 ± 1.02^b

29.24 ± 4.49^b

42.0 ± 5.11^a

25.98 ± 1.65^b

43.55 ± 6.76^a

6.53 ± 0.68^b

11.03 ± 0.83^b

14.49 ± 1.19^b

7.87 ± 0. 53^b

40.30 ± 2.71^a

18.96 ± 1.22 ^c

24.90 ± 0.35^bc

30.92 ± 4.09^b

19.66 ± 1.55^c

0.91 ± 0.05^b

1.54 ± 0.16^a

1.18 ± 0.13^ab

0.99 ± 0.15^ab

1.15 ± 0.10^ab

12.90 ± 2.20^a

9.34 ± 0.59^b

11.55 ± 1.20^ab

12.67 ± 0.30^a

8.71 ± 0.84^b

33.54 ± 6.23^a

32.067 ± 1.71^a

27.60 ± 3.09^a

33.86 ± 1.52^a

28.30 ± 1.70^a

0.84 ± 0.07^b

1.45 ± 0.17^a

1.41 ± 0.07^a

0.87 ± 0.05^b

1.38 ± 0.09 ^a

1.35 ± 0.13^b

2.50 ± 0.25^a

2.32 ± 0.18^a

1.43 ± 0.20^b

2.26 ± 0.16^a

2.36 ± 0.06^c

8.57 ± 0.54^a

4.54 ± 0.36^b

3.12 ± 0.41^c

4.90 ± 0.26^b