Table 3 Relative quantitative (mM) of discriminating metabolites of serum in obese diabetic rats (DG) and normal diet rats (NG) before treatment using Chenomx NMR Suite
Metabolites | Chemical shifts | Direction of Changes in DG | DG | NG |
|---|---|---|---|---|
Glucose | 5.22 | UP | 97.484 ± 7.8 | 32.122 ± 2.4 |
Pyruvate | 3.36 | - | 0.729 ± 0.05 | 0.684 ± 0.06 |
Lactate | 1.31 | UP | 16.413 ± 1.4 | 14.254 ± 1.2 |
valine | 3.6 | DOWN | 0.819 ± 0.04 | 2.147 ± 0.16 |
2-oxoglutarate | 2.42 | DOWN | 1.907 ± 0.2 | 3.892 ± 0.3 |
Succinate | 2.39 | DOWN | 0.792 ± 0.08 | 1.153 ± 0.1 |
acetate | 1.91 | DOWN | 1.159 ± 0.08 | 2.114 ± 0.2 |
Acetoacetate | 3.42 | UP | 20.514 ± 2.6 | 7.387 ± 0.5 |
3-hydroxybutyrate | 1.19 | UP | 7.547 ± 0.6 | 1.427 ± 0.09 |
Choline | 3.51 | UP | 17.588 ± 1.8 | 5.864 ± 0.6 |
Allantoin | 5.38 | DOWN | 0.449 ± 0.03 | 0.952 ± 0.06 |
Creatine | 3.91 | UP | 6.473 ± 0.5 | 2.181 ± 0.1 |
Isoleucine | 0.92 | DOWN | 1.111 ± 0.07 | 1.337 ± 0.1 |
Hippurate | 3.96 | DOWN | 0.516 ± 0.01 | 1.640 ± 0.13 |