Fig. 4

The effect of the botanical test formula on oral glucose tolerance. Serum glucose levels (a) and AUC (b) in a chronic HFD fed and an acute alloxan induced model of insulin resistance and T2DM treated with the botanical test formula comprised of fenugreek seed, mulberry leaf and American ginseng for 33 d. Animals were fasted 3 h followed by an administration of an oral glucose load (2.5 g/kg) and blood was collected at 0, and 0.5 and 2 h post challenge. Naïve control (n = 10); model control (n = 10); 1× (n = 10); 2× (n = 9); 4× (n = 7). Data are presented as mean ± SD. ^### P < 0.001 vs. naïve control group, ^*** P < 0.001, ^** P < 0.01 and ^* P < 0.05 vs. model control group