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Table 6 Body weight, organ weight and serum liver enzyme profile of normal and 5 g/kg body weight of Xeniji treated mice for 30 days of subchronic toxicity study

From: In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™

  Normal Xeniji 0.1 Xeniji 1.0 Xeniji 2.0
Day 0 BW (g) 20.42 ± 0.125 18.96 ± 0.271 19.96 ± 1.297 19.67 ± 1.145
Day 28 BW (g) 24.52 ± 1.370 22.91 ± 1.023 23.93 ± 1.837 23.52 ± 1.116
BW gain (g) 4.10 ± 1.245 3.96 ± 0.752 3.97 ± 0.541 3.86 ± 0.029
Liver/BW ratio 0.04 ± 0.005 0.04 ± 0.001 0.04 ± 0.004 0.04 ± 0.009
Kidney/BW ratio 0.01 ± 0.001 0.01 ± 0.001 0.01 ± 0.001 0.01 ± 0.001
Spleen/BW ratio 0.003 ± 0.000 0.003 ± 0.000 0.003 ± 0.000 0.003 ± 0.000
Glucose (mmol/L) 5.50 ± 0.99 5.40 ± 0.07 5.13 ± 0.76 5.00 ± 0.41
ALT (U/L) 53.68 ± 3.32 44.62 ± 1.83*# 44.33 ± 4.76* 43.55 ± 2.21*#
ALP (U/L) 72.33 ± 3.84 72.67 ± 3.37 79.67 ± 4.80 78.83 ± 1.89
AST (U/L) 103.97 ± 4.15 108.32 ± 2.10 108.04 ± 2.93 107.21 ± 5.83
Creatinine (μmol/L) 43.50 ± 0.40 42.00 ± 0.40 43.00 ± 0.95 42.50 ± 0.21
  1. *and #indicates a significant difference compared with the normal control group at p < 0.05 and p < 0.001