TY - JOUR AU - Xu, K. Z. -. Y. AU - Zhu, C. AU - Kim, M. S. AU - Yamahara, J. AU - Li, Y. PY - 2009 DA - 2009// TI - Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity JO - J Ethnopharmacol VL - 123 UR - https://doi.org/10.1016/j.jep.2009.03.035 DO - 10.1016/j.jep.2009.03.035 ID - Xu2009 ER - TY - JOUR AU - Loef, M. AU - Walach, H. PY - 2013 DA - 2013// TI - Midlife obesity and dementia: meta-analysis and adjusted forecast of dementia prevalence in the united states and china JO - Obesity VL - 21 UR - https://doi.org/10.1002/oby.20037 DO - 10.1002/oby.20037 ID - Loef2013 ER - TY - JOUR AU - Anstey, K. AU - Cherbuin, N. AU - Budge, M. AU - Young, J. PY - 2011 DA - 2011// TI - Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies JO - Obes Rev VL - 12 UR - https://doi.org/10.1111/j.1467-789X.2010.00825.x DO - 10.1111/j.1467-789X.2010.00825.x ID - Anstey2011 ER - TY - JOUR AU - Arnoldussen, I. A. AU - Kiliaan, A. J. AU - Gustafson, D. R. PY - 2014 DA - 2014// TI - Obesity and dementia: adipokines interact with the brain JO - Eur Neuropsychopharmacol VL - 24 UR - https://doi.org/10.1016/j.euroneuro.2014.03.002 DO - 10.1016/j.euroneuro.2014.03.002 ID - Arnoldussen2014 ER - TY - STD TI - Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7(3):270–9. ID - ref5 ER - TY - STD TI - Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol. 2010;219(1–2):25–32. ID - ref6 ER - TY - JOUR AU - Ward, M. A. AU - Carlsson, C. M. AU - Trivedi, M. A. AU - Sager, M. A. AU - Johnson, S. C. PY - 2005 DA - 2005// TI - The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study JO - BMC Neurol VL - 5 UR - https://doi.org/10.1186/1471-2377-5-23 DO - 10.1186/1471-2377-5-23 ID - Ward2005 ER - TY - JOUR AU - Whitmer, R. A. AU - Gunderson, E. P. AU - Quesenberry, C. P. AU - Zhou, J. AU - Yaffe, K. PY - 2007 DA - 2007// TI - Body mass index in midlife and risk of Alzheimer disease and vascular dementia JO - Curr Alzheimer Res VL - 4 UR - https://doi.org/10.2174/156720507780362047 DO - 10.2174/156720507780362047 ID - Whitmer2007 ER - TY - STD TI - Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 2005;62(10):1556–60. ID - ref9 ER - TY - STD TI - Gustafson D, Bäckman K, Waern M, Östling S, Guo X, Zandi P, et al. Adiposity indicators and dementia over 32 years in Sweden. Neurology. 2009;73(19):1559–66. ID - ref10 ER - TY - JOUR AU - Waldstein, S. AU - Katzel, L. PY - 2006 DA - 2006// TI - Interactive relations of central versus total obesity and blood pressure to cognitive function JO - Int J Obes VL - 30 UR - https://doi.org/10.1038/sj.ijo.0803114 DO - 10.1038/sj.ijo.0803114 ID - Waldstein2006 ER - TY - JOUR AU - Pannacciulli, N. AU - Parigi, A. AU - Chen, K. AU - Le, D. S. N. AU - Reiman, E. M. AU - Tataranni, P. A. PY - 2006 DA - 2006// TI - Brain abnormalities in human obesity: a voxel-based morphometric study JO - NeuroImage VL - 31 UR - https://doi.org/10.1016/j.neuroimage.2006.01.047 DO - 10.1016/j.neuroimage.2006.01.047 ID - Pannacciulli2006 ER - TY - STD TI - Businaro R, Ippoliti F, Ricci S, Canitano N, Fuso A. Alzheimer's disease promotion by obesity: induced mechanisms—molecular links and perspectives. Current gerontology and geriatrics research. 2012;2012 ID - ref13 ER - TY - JOUR AU - Delgado, T. C. AU - Violante, I. R. AU - Nieto-Charques, L. AU - Cerdán, S. PY - 2011 DA - 2011// TI - Neuroglial metabolic compartmentation underlying leptin deficiency in the obese ob/ob mice as detected by magnetic resonance imaging and spectroscopy methods JO - J Cereb Blood Flow Metab VL - 31 UR - https://doi.org/10.1038/jcbfm.2011.134 DO - 10.1038/jcbfm.2011.134 ID - Delgado2011 ER - TY - JOUR AU - Chattipakorn, S. AU - Pongpanparadorn, A. AU - Pratchayasakul, W. AU - Pongchaidacha, A. AU - Ingkaninan, K. AU - Chattipakorn, N. PY - 2007 DA - 2007// TI - Tabernaemontana divaricata Extract inhibits neuronal acetylcholinesterase activity in rats JO - J Ethnopharmacol VL - 110 UR - https://doi.org/10.1016/j.jep.2006.09.007 DO - 10.1016/j.jep.2006.09.007 ID - Chattipakorn2007 ER - TY - JOUR AU - Bonfleur, M. AU - Brito, N. AU - Grassiolli, S. AU - Mathias, P. C. F. AU - Silva, A. C. M. AU - Balbo, S. PY - 2000 DA - 2000// TI - Altered brain acetylcholinesterase activity in MSG-induced obese rats JO - Diabetes research VL - 35 ID - Bonfleur2000 ER - TY - JOUR AU - Zhang, X. AU - Dong, F. AU - Ren, J. AU - Driscoll, M. J. AU - Culver, B. PY - 2005 DA - 2005// TI - High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex JO - Exp Neurol VL - 191 UR - https://doi.org/10.1016/j.expneurol.2004.10.011 DO - 10.1016/j.expneurol.2004.10.011 ID - Zhang2005 ER - TY - STD TI - Braidy N, Selvaraju S, Essa MM, Vaishnav R, Al-Adawi S, Al-Asmi A, et al. Abd Alrahman Alobaidy A, Lakhtakia R. Guillemin GJ: Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons Oxidative medicine and cellular longevity. 2013;2013 ID - ref18 ER - TY - JOUR AU - Devore, E. E. AU - Grodstein, F. AU - Rooij, F. A. PY - 2010 DA - 2010// TI - Dietary antioxidants and long-term risk of dementia JO - Arch Neurol VL - 67 UR - https://doi.org/10.1001/archneurol.2010.144 DO - 10.1001/archneurol.2010.144 ID - Devore2010 ER - TY - JOUR AU - Galasko, D. R. AU - Peskind, E. AU - Clark, C. M. PY - 2012 DA - 2012// TI - Antioxidants for alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures JO - Arch Neurol VL - 69 UR - https://doi.org/10.1001/archneurol.2012.85 DO - 10.1001/archneurol.2012.85 ID - Galasko2012 ER - TY - STD TI - Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, et al. Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Front Biosci. 2009;14(3):76–97. ID - ref21 ER - TY - JOUR AU - Johanningsmeier, S. D. AU - Harris, G. K. PY - 2011 DA - 2011// TI - Pomegranate as a functional food and nutraceutical source JO - Annu Rev Food Sci Technol VL - 2 UR - https://doi.org/10.1146/annurev-food-030810-153709 DO - 10.1146/annurev-food-030810-153709 ID - Johanningsmeier2011 ER - TY - JOUR AU - Pérez-Vicente, A. AU - Gil-Izquierdo, A. AU - García-Viguera, C. PY - 2002 DA - 2002// TI - In vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin C JO - J Agric Food Chem VL - 50 UR - https://doi.org/10.1021/jf0113833 DO - 10.1021/jf0113833 ID - Pérez-Vicente2002 ER - TY - JOUR AU - Gil, M. I. AU - Tomás-Barberán, F. A. AU - Hess-Pierce, B. AU - Holcroft, D. M. AU - Kader, A. A. PY - 2000 DA - 2000// TI - Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing JO - J Agric Food Chem VL - 48 UR - https://doi.org/10.1021/jf000404a DO - 10.1021/jf000404a ID - Gil2000 ER - TY - STD TI - Aviram M, Volkova N, Coleman R, Dreher M, Reddy MK, Ferreira D, et al. Pomegranate Phenolics from the peels, arils, and flowers are Antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E0) mice and in vitro in cultured macrophages and lipoproteins. J Agric Food Chem. 2008;56(3):1148–57. ID - ref25 ER - TY - STD TI - Lei F, Zhang XN, Wang W, Xing DM, Xie WD, Su H, et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes. 2007;31(6):1023–9. ID - ref26 ER - TY - STD TI - Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 2002;71(3):203–17. ID - ref27 ER - TY - STD TI - Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol Dis. 2006;24(3):506–15. ID - ref28 ER - TY - STD TI - Zou X, Yan C, Shi Y, Cao K, Xu J, Wang X, et al. Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal. 2014;21(11):1557–70. ID - ref29 ER - TY - STD TI - Harzallah A, Hammami M, Kępczyńska MA, Hislop DC, Arch JR, Cawthorne MA, et al. Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model. Arch Physiol Biochem. 2016;122(2):75–87. ID - ref30 ER - TY - STD TI - Vroegrijk IOCM, van Diepen JA, van den Berg S, Westbroek I, Keizer H, Gambelli L, et al. Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. Food Chem Toxicol. 2011;49(6):1426–30. ID - ref31 ER - TY - STD TI - Cao K, Xu J, Pu W, Dong Z, Sun L, Zang W, et al. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci Rep. 2015;5:14014. ID - ref32 ER - TY - STD TI - Rodriguez J, Gilson H, Jamart C, Naslain D, Pierre N, Deldicque L, et al. Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice. Eur J Nutr. 2015;54(3):377–89. ID - ref33 ER - TY - JOUR AU - Choi, H. Y. AU - Jhun, E. J. AU - Lim, B. O. AU - Chung, I. M. AU - Kyung, S. H. AU - Park, D. K. PY - 2000 DA - 2000// TI - Application of flow injection—chemiluminescence to the study of radical scavenging activity in plants JO - Phytother Res VL - 14 UR - https://doi.org/3.0.CO;2-J DO - 3.0.CO;2-J ID - Choi2000 ER - TY - JOUR AU - Doctor, B. AU - Toker, L. AU - Roth, E. AU - Silman, I. PY - 1987 DA - 1987// TI - Microtiter assay for acetylcholinesterase JO - Anal Biochem VL - 166 UR - https://doi.org/10.1016/0003-2697(87)90590-2 DO - 10.1016/0003-2697(87)90590-2 ID - Doctor1987 ER - TY - JOUR AU - Draper, H. PY - 1990 DA - 1990// TI - Hadley M: [43] malondialdehyde determination as index of lipid peroxidation JO - Methods Enzymol VL - 186 UR - https://doi.org/10.1016/0076-6879(90)86135-I DO - 10.1016/0076-6879(90)86135-I ID - Draper1990 ER - TY - STD TI - Levine R: Determination of carbonyl content in oxidatively modified proteins/Levine RL, Garland D., Oliver CN, Amici A., Climent I., Lenz A.-G., Ahn B.-W., Shaltiel S., Stadtman ER. Methods in Enzymolology–1990–186–P:465–478. ID - ref37 ER - TY - JOUR AU - Sun, Y. AU - Oberley, L. W. AU - Li, Y. PY - 1988 DA - 1988// TI - A simple method for clinical assay of superoxide dismutase JO - Clin Chem VL - 34 ID - Sun1988 ER - TY - JOUR AU - Flohe, L. AU - Gunzler, W. A. PY - 1984 DA - 1984// TI - Assays of glutathione peroxidase JO - Methods Enzymol VL - 105 UR - https://doi.org/10.1016/S0076-6879(84)05015-1 DO - 10.1016/S0076-6879(84)05015-1 ID - Flohe1984 ER - TY - JOUR AU - Mathew, M. AU - Subramanian, S. PY - 2014 DA - 2014// TI - In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0086804 DO - 10.1371/journal.pone.0086804 ID - Mathew2014 ER - TY - JOUR AU - Bekir, J. AU - Mars, M. AU - Souchard, J. P. AU - Bouajila, J. PY - 2013 DA - 2013// TI - Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of pomegranate (Punica granatum) leaves JO - Food Chem Toxicol VL - 55 UR - https://doi.org/10.1016/j.fct.2013.01.036 DO - 10.1016/j.fct.2013.01.036 ID - Bekir2013 ER - TY - JOUR AU - Charradi, K. AU - Sebai, H. AU - Elkahoui, S. AU - Hassine, F. B. AU - Limam, F. AU - Aouani, E. PY - 2011 DA - 2011// TI - Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis JO - Cardiovasc Toxicol VL - 11 UR - https://doi.org/10.1007/s12012-010-9101-z DO - 10.1007/s12012-010-9101-z ID - Charradi2011 ER - TY - STD TI - Nasri R, Abdelhedi O, Jemil I, Daoued I, Hamden K, Kallel C, et al. Ameliorating effects of goby fish protein hydrolysates on high-fat-high-fructose diet-induced hyperglycemia, oxidative stress and deterioration of kidney function in rats. Chem Biol Interact. 2015;242:71–80. ID - ref43 ER - TY - JOUR AU - Melo, J. B. AU - Agostinho, P. AU - Oliveira, C. R. PY - 2003 DA - 2003// TI - Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide JO - Neurosci Res VL - 45 UR - https://doi.org/10.1016/S0168-0102(02)00201-8 DO - 10.1016/S0168-0102(02)00201-8 ID - Melo2003 ER - TY - JOUR AU - Schallreuter, K. U. AU - Elwary, S. M. A. AU - Gibbons, N. C. J. AU - Rokos, H. AU - Wood, J. M. PY - 2004 DA - 2004// TI - Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo JO - Biochem Biophys Res Commun VL - 315 UR - https://doi.org/10.1016/j.bbrc.2004.01.082 DO - 10.1016/j.bbrc.2004.01.082 ID - Schallreuter2004 ER - TY - JOUR AU - Paes, A. M. AU - Carniatto, S. R. AU - Francisco, F. A. AU - Brito, N. A. AU - Mathias, P. C. PY - 2006 DA - 2006// TI - Acetylcholinesterase activity changes on visceral organs of VMH lesion-induced obese rats JO - The International journal of neuroscience VL - 116 UR - https://doi.org/10.1080/00207450600920910 DO - 10.1080/00207450600920910 ID - Paes2006 ER - TY - JOUR AU - Ishige, K. AU - Schubert, D. AU - Sagara, Y. PY - 2001 DA - 2001// TI - Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms JO - Free Radic Biol Med VL - 30 UR - https://doi.org/10.1016/S0891-5849(00)00498-6 DO - 10.1016/S0891-5849(00)00498-6 ID - Ishige2001 ER - TY - STD TI - Jing P, Ye T, Shi H, Sheng Y, Slavin M, Gao B, et al. Antioxidant properties and phytochemical composition of China-grown pomegranate seeds. Food Chem. 2012;132(3):1457–64. ID - ref48 ER - TY - JOUR AU - Tezcan, F. AU - Gültekin-Özgüven, M. AU - Diken, T. AU - Özçelik, B. AU - Erim, F. B. PY - 2009 DA - 2009// TI - Antioxidant activity and total phenolic, organic acid and sugar content in commercial pomegranate juices JO - Food Chem VL - 115 UR - https://doi.org/10.1016/j.foodchem.2008.12.103 DO - 10.1016/j.foodchem.2008.12.103 ID - Tezcan2009 ER - TY - STD TI - Subash S, Essa MM, Al-Asmi A, Al-Adawi S, Vaishnav R, Braidy N, et al. Pomegranate from Oman alleviates the brain oxidative damage in transgenic mouse model of Alzheimer’s disease. Journal of Traditional and Complementary Medicine. 2014;4(4):232–8. ID - ref50 ER - TY - JOUR AU - Arao, K. AU - Yotsumoto, H. AU - Han, S. -. Y. AU - Nagao, K. AU - Yanagita, T. PY - 2004 DA - 2004// TI - The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells JO - Biosci Biotechnol Biochem VL - 68 UR - https://doi.org/10.1271/bbb.68.2643 DO - 10.1271/bbb.68.2643 ID - Arao2004 ER - TY - JOUR AU - Ahmed, M. A. E. AU - Morsy, E. M. AU - Ahmed, A. A. E. PY - 2014 DA - 2014// TI - Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats JO - Life Sci VL - 110 UR - https://doi.org/10.1016/j.lfs.2014.06.023 DO - 10.1016/j.lfs.2014.06.023 ID - Ahmed2014 ER - TY - JOUR AU - Moneim, A. E. A. PY - 2012 DA - 2012// TI - Antioxidant activities of Punica granatum (pomegranate) peel extract on brain of rats JO - Journal of Medicinal Plants Research VL - 6 ID - Moneim2012 ER - TY - JOUR AU - Yaidikar, L. AU - Byna, B. AU - Thakur, S. R. PY - 2014 DA - 2014// TI - Neuroprotective effect of punicalagin against cerebral ischemia reperfusion-induced oxidative brain injury in rats JO - J Stroke Cerebrovasc Dis VL - 23 UR - https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.07.020 DO - 10.1016/j.jstrokecerebrovasdis.2014.07.020 ID - Yaidikar2014 ER - TY - JOUR AU - Rauchova, H. AU - Ledvinkova, J. AU - Kalous, M. AU - Drahota, Z. PY - 1995 DA - 1995// TI - The effect of lipid peroxidation on the activity of various membrane-bound ATPases in rat kidney JO - Int J Biochem Cell Biol VL - 27 UR - https://doi.org/10.1016/1357-2725(94)00083-N DO - 10.1016/1357-2725(94)00083-N ID - Rauchova1995 ER - TY - JOUR AU - Dobrota, D. AU - Matejovicova, M. AU - Kurella, E. G. AU - Boldyrev, A. A. PY - 1999 DA - 1999// TI - Na/K-ATPase under oxidative stress: molecular mechanisms of injury JO - Cell Mol Neurobiol VL - 19 UR - https://doi.org/10.1023/A:1006909927287 DO - 10.1023/A:1006909927287 ID - Dobrota1999 ER - TY - JOUR AU - Lees, A. J. PY - 1993 DA - 1993// TI - Dopamine agonists in Parkinson's disease: a look at apomorphine JO - Fundamental & clinical pharmacology VL - 7 UR - https://doi.org/10.1111/j.1472-8206.1993.tb00226.x DO - 10.1111/j.1472-8206.1993.tb00226.x ID - Lees1993 ER - TY - STD TI - Mizrahi M, Friedman-Levi Y, Larush L, Frid K, Binyamin O, Dori D, et al. Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD. Nanomedicine. 2014;10(6):1353–63. ID - ref58 ER -