Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Table 6 Effect of Cynara scolymus leaves extracts on body weight gain of experimental groups of rats

Groups of treatment	Day1	Day 7	Day14	Day 21	Day 28
Cont	180.33 ± 0.57	182.13 ± 1.84	186.00 ± 1.09	197.50 ± 1.05	205.65 ± 4.92
Diab	181.48 ± 1.29^ns	176.85 ± 2.74^***	173.22 ± 1.04^***	166.66 ± 2.08^***	154.66 ± 5.50^***
Diab + Ethanol extract of leaves C. scolymus (200 mg/kg)	185.00 ± 6.24^ns	195.39 ± 0.74^###£	199.41 ± 0.71^###£££	204.33 ± 1.90^###£££	207.56 ± 2.44^###£££
Diab + Ethanol extract of leaves C. scolymus (400 mg/kg)	180.75 ± 0.55^£££	184.82 ± 0.23^###£££	188.04 ± 0.94^###£££	192.00 ± 2.64^###	196.00 ± 1.00^###
Diab + Acarbose (12 mg/kg)	189.70 ± 0.60^#	192.76 ± 1.36^###	193.20 ± 0.82^###	194.13 ± 2.19^###	197.16 ± 2.46^###

Diabetic rats were orally administered with the ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). ^*** p ≤ 0.001 were considered significant compared to control group; ^# p ≤ 0.05, ^### p ≤ 0.001 were considered significant compared to diabetic rat.; ^£ p ≤ 0.05, ^£££ p ≤ 0.001 compared to diabetic rats treated with acarbose; ^ns: non-significant changes between diabetic treated groups vs. the control group after 28 days treatment

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