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Table 10 Effect of Cynara scolymus leaves extracts on SOD, CAT, GSH, MDA and AOPP levels in liver, pancreas and kidney of experimental groups of rats

From: Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

Groups

SOD (U/mg protein)

CAT (mmol H2O2/min/mg protein)

GSH (mg/mg protein

MDA (nmol MDA/mg protein)

AOPP (nmol/mg protein)

Liver

 Control

75.62 ± 7.48

1.79 ± 1.34

33.88 ± 1.00

10.00 ± 5.25

0.20 ± 0.16

 Diab

55.21 ± 4.98*

0.63 ± 70.20*

13.41 ± 0.39***

25.76 ± 1.21*

0.47 ± 0.05 **

 Diab + Ethanol extract of leaves C. scolymus (200 mg /kg)

72.14 ± 4.27 #£

1.89 ± 0.56 ###£

52.73 ± 9.82###

16.29 ± 5.59 ##££

0.31 ± 0.17###£

 Diab + Ethanol extract of leaves C. scolymus (400 mg /kg)

64.85 ± 7.39#£

2.19 ± 0.20 ##£

34.74 ± 2.49#

12.74 ± 7.85 #£

0.26 ± 0.25 ##££

 Diab + Acarbose (12 mg/kg)

91.52 ± 1.58#

1.85 ± 1.91##

30.57 ± 2.46##

11.47 ± 6.63###

0.26 ± 0.22 ##

Pancreas

 Control

87.71 ± 3.58

1.25 ± 0.44

6.67 ± 1.93

9.21 ± 1.75

0.27 ± 0.14

 Diab

29.62 ± 2.23 ***

0.11 ± 0.82***

2.01 ± 1.02*

23.91 ± 7.70**

0.63 ± 0.21*

 Diab + ethanol extract of C. scolymus (200 mg /kg)

64.43 ± 5.23 ##££

1.16 ± 0.52#£

6.65 ± 3.69#

11.2 ± 17.26 #£

0.19 ± 0.20 #£

 Diab + ethanol extract of C. scolymus (200 mg /kg)

43.63 ± 1.06 #££

0.89 ± 0.76 ##£

5.96 ± 5.29#

17.56 ± 3.73#£

0.17 ± 0.15 ##££

 Diab + Acarbose (12 mg/kg)

55.15 ± 4.92##

0.78 ± 0.12 ###

2.46 ± 1.23##

16.71 ± 1.75#

0.31 ± 0.17#

Kidney

 Control

46.59 ± 5.10

2.08 ± 0.26

17.25 ± 3.97

21.22 ± 2.23

0.10 ± 0.04

 Diab

11.14 ± 3.70 *

0.60 ± 0.36***

7.51 ± 0.29*

34.75 ± 1.23**

0.27 ± 0.04**

 Diab + ethanol extract of leaves C. scolymus (200 mg/kg)

18.23 ± 5.54 ##££

2.02 ± 0.57 ##£

20.07 ± 1.52#

16.03 ± 7.90##£

0.11 ± 0.00 ###££

 Diab + ethanol extract of leaves C. scolymus (400 mg/kg)

21.66 ± 1.83#

1.28 ± 0.57 #£

23.54 ± 8.72#

20.64 ± 1.40#£££

0.12 ± 0.01 ##£

 Diab + Acarbose (12 mg/kg)

28.36 ± 1.67 ##

1.96 ± 0.47 ###

18.00 ± 0.87##

19.31 ± 6.50###

0.16 ± 0.02 ###

  1. Diabetic rats were orally administered with ethanol extract from leaves of C. scolymus and acarbose at the doses mentioned earlier for 28 days. Values are given as means ± SD (n = 8). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001 were considered significant compared to control group; # p ≤ 0.05, ## p ≤ 0.001, ###p ≤ 0.001 were considered significant compared to diabetic rat.; £ p ≤ 0.05, ££ p ≤ 0.01 £££ p ≤ 0.001 compared to diabetic rats treated with acarbose