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Table 3 RES-induced changes of the chemokine and cytokine profile in human PBLs

From: Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells

Metabolite LPS/INF-γ alone RES (25 μM) + LPS/INF-γ p
PGE2 [pg/mL] 4975 ± 483 612 ± 238 0.005
IL-6 [ng/mL] 76.8 ± 5.5 135.1 ± 16.7 0.044
IL-1β [ng/mL] 11.6 ± 1.3 22.3 ± 2.2 0.009
TNF-α [pg/mL] 2762 ± 393 1195 ± 320 0.04
CCL2/MCP-1 [pg/mL] 804 ± 60 352 ± 26 0.002
CCL4/MIP-1β [ng/mL] 70.8 ± 6.2 123 ± 22 0.16
CCL5/RANTES [pg/mL] 1032 ± 220 798 ± 59 0.05
CXCL10/IP-10 [pg/mL] 2072 ± 110 16,758 ± 2649 0.026
GM-CSF 17.9 ± 3.3 15.2 ± 3.0 0.29
  1. Freshly isolated PBLs were stimulated with LPS/INF-γ in the presence of RES and cultured for 24 h. Metabolites were determined in the culture supernatants by multiplex ELISA. Mean (±SD) of triplicate cultures from three donors are shown. p values were calculated between treatments ‘LPS/INF-γ -alone’ versus ‘RES + LPS/INF-γ’