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Table 3 RES-induced changes of the chemokine and cytokine profile in human PBLs

From: Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells

Metabolite

LPS/INF-γ alone

RES (25 μM) + LPS/INF-γ

p

PGE2 [pg/mL]

4975 ± 483

612 ± 238

0.005

IL-6 [ng/mL]

76.8 ± 5.5

135.1 ± 16.7

0.044

IL-1β [ng/mL]

11.6 ± 1.3

22.3 ± 2.2

0.009

TNF-α [pg/mL]

2762 ± 393

1195 ± 320

0.04

CCL2/MCP-1 [pg/mL]

804 ± 60

352 ± 26

0.002

CCL4/MIP-1β [ng/mL]

70.8 ± 6.2

123 ± 22

0.16

CCL5/RANTES [pg/mL]

1032 ± 220

798 ± 59

0.05

CXCL10/IP-10 [pg/mL]

2072 ± 110

16,758 ± 2649

0.026

GM-CSF

17.9 ± 3.3

15.2 ± 3.0

0.29

  1. Freshly isolated PBLs were stimulated with LPS/INF-γ in the presence of RES and cultured for 24 h. Metabolites were determined in the culture supernatants by multiplex ELISA. Mean (±SD) of triplicate cultures from three donors are shown. p values were calculated between treatments ‘LPS/INF-γ -alone’ versus ‘RES + LPS/INF-γ’