Table 1 Anti-mycobacterial activity of extracts, compounds and derivatives from C. dentata
From: Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae)
Samples | MIC in μg/ml | Cytotoxicity (μg/ml) | Selectivity index | |||
|---|---|---|---|---|---|---|
HEK293 | HepG2 | HEK 293 | HepG2 | |||
Fractions | Acetone | 44.2 | ||||
Ethanol | >50 | |||||
Chloroform | >50 | |||||
Methanol | 22.2 | |||||
Isolated compounds | β-sitosterol | >50 | >300 | >300 | 6 | 6 |
Betulinic acid | >50 | >300 | >300 | 6 | 6 | |
Ursolic acid | >50 | 122.4 | >300 | 2.45 | 6 | |
Lupeol | >50 | 278.8 | 289.4 | 5.58 | 5.79 | |
Derivatives | Betulinic acid acetate | 19.8 | 357.80 ± 2.14 | 358.20 ± 2.23 | 18.1 | 18.1 |
Ursolic acid acetate | 3.4 | 340.02 ± 4.12 | 328.39 ± 3.10 | 100 | 96.59 | |
Positive controls | MIC in μM | |||||
Rifampicin | 0.02 | |||||
Isoniazid | 0.43 | |||||
Streptomycin | 0.25 | |||||
TMC207 | 0.02 | |||||