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Table 1 Anti-mycobacterial activity of extracts, compounds and derivatives from C. dentata

From: Isolation of anti-mycobacterial compounds from Curtisia dentata (Burm.f.) C.A.Sm (Curtisiaceae)

Samples MIC in μg/ml Cytotoxicity (μg/ml) Selectivity index
   HEK293 HepG2 HEK 293 HepG2
Fractions Acetone 44.2     
Ethanol >50     
Chloroform >50     
Methanol 22.2     
Isolated compounds β-sitosterol >50 >300 >300 6 6
Betulinic acid >50 >300 >300 6 6
Ursolic acid >50 122.4 >300 2.45 6
Lupeol >50 278.8 289.4 5.58 5.79
Derivatives Betulinic acid acetate 19.8 357.80 ± 2.14 358.20 ± 2.23 18.1 18.1
Ursolic acid acetate 3.4 340.02 ± 4.12 328.39 ± 3.10 100 96.59
Positive controls   MIC in μM     
Rifampicin 0.02     
Isoniazid 0.43     
Streptomycin 0.25     
TMC207 0.02     
  1. (Cytotoxicity data for isolated compounds has been extracted from [43])