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Table 6 Glucose and insulin concentrations obtained after the administration of an oral 3 g glucose load to diabetic rabbits (n = 6) treated with oral metformin (30 mg/kg) and Plantago ovata husk (300 mg/kg)

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Time (min) Glucose (mg/dL) Insulin (mUI/L)
Standard chow (group 3) Supplemented chow (group 6) p valuesa Standard chow (group 3) Supplemented chow (group 6) p valuesa
0 457.7 ± 37.74 400.9 ± 79.04 0.133 0.936 ± 0.238 0.333 ± 0.070 0.000
30 528.7 ± 26.83 471.4 ± 52.61 0.039 1.773 ± 0.876 0.646 ± 0.169 0.011
60 573.0 ± 18.86 508.6 ± 81.48 0.089 3.579 ± 2.399 1.124 ± 0.652 0.036
120 543.0 ± 58.18 489.7 ± 66.09 0.102 1.517 ± 0.538 0.832 ± 0.397 0.031
180 530.2 ± 53.90 407.1 ± 58.62 0.004 1.075 ± 0.534 0.692 ± 0.333 0.167
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