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Table 2 Cytotoxicity of tested plant extracts and doxorubicin towards cancer cell lines and normal cells as determined by the neutral red assay

From: Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

Samples Cell lines, IC50 values in μg/mL and selectivity indexa (in bracket)
A549 SPC212 HepG2 DLD-1 MCF-7 CRL2120
Elephantopus mollis (whole plant; EMW) 24.38 ± 1.86 4.05 ± 0.69 3.74 ± 0.07 3.29 ± 0.04 3.97 ± 0.48 >40
(>1.64) (>9.89) (>10.70) (>12.18) (>10.08)  
Enantia chlorantha (bark; ECB) >40 25.16 ± 1.30 17.32 ± 0.13 >40 >40 >40
  (>1.59) (>12.31)    
Kalanchoe crenata (leaves; KCL) 8.23 ± 0.15(>4.86) 2.33 ± 0.23 28.96 ± 3.51 23.87 ± 1.69 19.31 ± 0.79 >40
  (>17.20) (>1.38) (>1.68) (>2.07)  
Lophira alata (bark; LAB) >40 >40 32.98 ± 4.20 >40 >40 >40
   (>1.21)    
Millettia macrophylla (leaves; MML) >40 7.54 ± 0.26 2.01 ± 0.04 31.02 ± 2.86 25.99 ± 1.68 >40
  (>5.31) (>19.90) (>1.29) (>1.54)  
Phragmanthera capitata (leaves; PCL) >40 >40 >40 >40 >40 >40
Doxorubicin 0.55 ± 0.11 0.04 ± 0.01 0.10 ± 0.01 0.20 ± 0.02 0.19 ± 0.03 0.32 ± 0.06
(0.58) (8.63) (3.18) (1.58) (1.67)  
  1. aThe selectivity index was determined as the ratio of IC50 value in the CRL2120 normal fibroblasts divided by the IC50 in the cancer cell lines. In bold: significant activity [7, 23, 24, 45]