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Table 2 Cytotoxicity of tested plant extracts and doxorubicin towards cancer cell lines and normal cells as determined by the neutral red assay

From: Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

Samples

Cell lines, IC50 values in μg/mL and selectivity indexa (in bracket)

A549

SPC212

HepG2

DLD-1

MCF-7

CRL2120

Elephantopus mollis (whole plant; EMW)

24.38 ± 1.86

4.05 ± 0.69

3.74 ± 0.07

3.29 ± 0.04

3.97 ± 0.48

>40

(>1.64)

(>9.89)

(>10.70)

(>12.18)

(>10.08)

 

Enantia chlorantha (bark; ECB)

>40

25.16 ± 1.30

17.32 ± 0.13

>40

>40

>40

 

(>1.59)

(>12.31)

   

Kalanchoe crenata (leaves; KCL)

8.23 ± 0.15(>4.86)

2.33 ± 0.23

28.96 ± 3.51

23.87 ± 1.69

19.31 ± 0.79

>40

 

(>17.20)

(>1.38)

(>1.68)

(>2.07)

 

Lophira alata (bark; LAB)

>40

>40

32.98 ± 4.20

>40

>40

>40

  

(>1.21)

   

Millettia macrophylla (leaves; MML)

>40

7.54 ± 0.26

2.01 ± 0.04

31.02 ± 2.86

25.99 ± 1.68

>40

 

(>5.31)

(>19.90)

(>1.29)

(>1.54)

 

Phragmanthera capitata (leaves; PCL)

>40

>40

>40

>40

>40

>40

Doxorubicin

0.55 ± 0.11

0.04 ± 0.01

0.10 ± 0.01

0.20 ± 0.02

0.19 ± 0.03

0.32 ± 0.06

(0.58)

(8.63)

(3.18)

(1.58)

(1.67)

 
  1. aThe selectivity index was determined as the ratio of IC50 value in the CRL2120 normal fibroblasts divided by the IC50 in the cancer cell lines. In bold: significant activity [7, 23, 24, 45]