A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties.

Table 4 Anti-inflammatory activity of Prunus domestica gum-loaded gold nanoparticles

Treatment	1st h	2nd h	3rd h	4th h	5th h
Group 1 Saline	0.247 ± 0.026	0.250 ± 0.022	0.265 ± 0.013	0.250 ± 0.014	0.250 ± 0.016
Group 2 Carrageenan	0.355 ± 0.013^###	0.370 ± 0.026^###	0.385 ± 0.021^###	0.397 ± 0.026^###	0.405 ± 0.013^###
Group 3 Diclofenac (50 mg/kg)	0.287 ± 0.029**	0.265 ± 0.019***	0.265 ± 0.031***	0.287 ± 0.025***	0.305 ± 0.012***
Group 4 Gum (200 mg/kg)	0.302 ± 0.009*	0.290 ± 0.008***	0.295 ± 0.013***	0.305 ± 0.013***	0.315 ± 0.019***
Group 5 Gum (400 mg/kg)	0.282 ± 0.017***	0.292 ± 0.012***	0.287 ± 0.012***	0.280 ± 0.022***	0.290 ± 0.018***
Group 6 Gold nanoparticles (40 mg/kg)	0.305 ± 0.021*	0.307 ± 0.012***	0.305 ± 0.012***	0.302 ± 0.015***	0.317 ± 0.026***
Group 7 Gold nanoparticles (80 mg/kg)	0.295 ± 0.013**	0.287 ± 0.017***	0.295 ± 0.013***	0.287 ± 0.022***	0.300 ± 0.018***

Values expressed as mean paw volume in mL ± SD. ^### P <0.001 compared to group 1. * P <0.05, ** P <0.01, *** P <0.001 compared to group 2. One-way ANOVA followed by Tukey’s post hoc test. Results are the means of 6 animals per group

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