Skip to main content

Table 3 Antiviral activities of phenanthrenes from Bletilla striata in MDCK cells

From: Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus

Compound

CC50

Simultaneous treatment

Post-treatment

 

(μM)a

IC50 (μM)b

SIc

IC50 (μM)b

SIc

1

200.8 ± 18.6

-

-

-

-

2

67.9 ± 13.1

28.6 ± 4.3

2.3

31.4 ± 2.1

2.2

3

50.3 ± 6.2

20.4 ± 3.2

2.5

22.6 ± 1.8

2.2

4

80.0 ± 20.1

14.6 ± 2.4

5.5

18.4 ± 3.1

4.3

5

96.8 ± 15.6

-

-

-

-

6

106.4 ± 21.2

33.8 ± 2.7

3.1

37.3 ± 3.2

2.8

7

129.5 ± 15.6

28.5 ± 2.8

4.5

31.2 ± 2.2

4.1

8

110.6 ± 17.3

-

-

-

-

9

160.3 ± 20.4

-

-

-

-

10

141.6 ± 25.0

43.3 ± 5.3

3.3

42.3 ± 3.9

3.4

11

118.6 ± 19.6

38.6 ± 2.9

3.1

35.2 ± 3.7

3.4

12

115.7 ± 16.8

-

-

-

-

Oseltamivir

598.8 ± 62.1

4.9 ± 0.9

122.2

0.9 ± 0.2

665.3

  1. aCC50: 50% cytotoxic concentration
  2. bIC50: 50% inhibitory concentration
  3. cSI: selective index; CC50mean/IC50mean
  4. -: The results showed that antiviral effects against A/Sydney/5/97(H3N2) were less than 50% inhibition