Fig. 3

Quantitative analysis of baicalin in SbE and effects of SbE and baicalin on the cell viability in CSC and CRC. a LC-MS analysis of baicalin in SbE. b Baicalin peak area in LC-MS as a function of baicalin concentration (correlation coefficient, R = 0.999) and the percent content of baicalin in SbE. Cells were exposed 200 ~ 400 μg/mL of SbE or 28 ~ 56 μM of baicalin for 24 h. Cell viability according to SbE or baicalin treatment in (c) CSC and (d) CRC was determined by MTT assay. Cells were exposed 100 ~ 400 μg/mL of SbE for 24 h. e Cell viability according to various concentrations of SbE treatment in CSC and CRC was determined by MTT assay. Each value is the mean ± SD. p < 0.05 was taken to define statistical significance. Two tailed Student’s t-test