Table 7 ROC Curve of Lipid Peroxide, Oxidized Glutathione, Reduced Glutathione, Glutathione S-transferase together with GSH/GSSG ratio between neuro-intoxicated, protected and therapeutically treated rat pups compared to healthy control
Parameters | Groups | Area under the curve | Cutoff value | Sensitivity % | Specificity % |
|---|---|---|---|---|---|
LPO (U\ml) | VPA | 0.545 | 3.250 | 90.0% | 50.0% |
VPA-CUR | 0.915 | 2.650 | 80.0% | 100.0% | |
CUR | 0.805 | 3.150 | 80.0% | 70.0% | |
GSH (mmol/L) | VPA | 1.000 | 200.350 | 100.0% | 100.0% |
VPA-CUR | 1.000 | 210.320 | 100.0% | 100.0% | |
CUR | 0.570 | 278.195 | 40.0% | 90.0% | |
GSSG (pg/ml) | VPA | 1.000 | 137.500 | 100.0% | 100.0% |
VPA-CUR | 1.000 | 175.000 | 100.0% | 100.0% | |
CUR | 0.935 | 117.500 | 90.0% | 90.0% | |
GSH (pg\ml) | VPA | 1.000 | 6260.938 | 100.0% | 100.0% |
VPA-CUR | 1.000 | 6572.500 | 100.0% | 100.0% | |
CUR | 0.570 | 8693.594 | 40.0% | 90.0% | |
GSH + GSSG | VPA | 1.000 | 6435.938 | 100.0% | 100.0% |
VPA-CUR | 1.000 | 6762.500 | 100.0% | 100.0% | |
CUR | 0.580 | 8798.594 | 40.0% | 90.0% | |
GSH/GSSG | VPA | 1.000 | 45.417 | 100.0% | 100.0% |
VPA-CUR | 1.000 | 40.685 | 100.0% | 100.0% | |
CUR | 0.900 | 71.255 | 90.0% | 80.0% |