Table 6 ROC Curve of Interleukin-6, Interferon Gamma, cytochrome P450, Serotonin, Glutamine, Glutamate together with Glutamate/Glutamine ratio in neuro-intoxicated, protected and therapeutically treated rat pups compared to healthy control
Parameters | Groups | Area under the curve | Cutoff value | Sensitivity % | Specificity % |
|---|---|---|---|---|---|
IL-6 (pg\ml) | VPA | 0.625 | 9.832 | 80.0% | 40.0% |
VPA-CUR | 0.740 | 11.165 | 90.0% | 60.0% | |
CUR | 0.635 | 12.945 | 80.0% | 50.0% | |
IFN-γ (pg\ml) | VPA | 0.750 | 318.225 | 90.0% | 70.0% |
VPA-CUR | 0.780 | 327.520 | 90.0% | 70.0% | |
CUR | 0.805 | 365.885 | 100.0% | 60.0% | |
CYP450 (ng\ml) | VPA | 0.790 | 37.085 | 80.0% | 80.0% |
VPA-CUR | 0.590 | 37.471 | 50.0% | 90.0% | |
CUR | 0.790 | 37.630 | 80.0% | 90.0% | |
5HT (ng\ml) | VPA | 0.620 | 137.220 | 60.0% | 90.0% |
VPA-CUR | 0.625 | 140.965 | 60.0% | 80.0% | |
CUR | 0.550 | 157.750 | 50.0% | 80.0% | |
GSTs (mU\ml) | VPA | 0.620 | 17.100 | 90.0% | 40.0% |
VPA-CUR | 0.675 | 12.450 | 50.0% | 90.0% | |
CUR | 0.730 | 12.450 | 60.0% | 90.0% | |
Glutamin (pmol\ml) | VPA | 0.610 | 2365.295 | 90.0% | 40.0% |
VPA-CUR | 0.890 | 1984.715 | 90.0% | 80.0% | |
CUR | 0.840 | 2007.865 | 90.0% | 80.0% | |
Glutamate (nmol\ml) | VPA | 0.590 | 244.955 | 90.0% | 50.0% |
VPA-CUR | 0.645 | 234.870 | 70.0% | 70.0% | |
CUR | 0.810 | 213.790 | 70.0% | 100.0% | |
Glutamate/Glutamin ratio | VPA | 0.810 | 0.111 | 100.0% | 60.0% |
VPA-CUR | 0.820 | 0.122 | 80.0% | 90.0% | |
CUR | 0.500 | 0.115 | 60.0% | 70.0% |