Melicope ptelefolia leaf extracts exhibit antioxidant activity and exert anti-proliferative effect with apoptosis induction on four different cancer cell lines

Table 2 Antioxidant activities of MP leaf extracts

Extraction solvent	FRAP(mmol Fe²⁺/g DE)	ABTS^●+ (IC₅₀ μg/mL)	DPPH^●(IC₅₀ μg/mL)	CAA (Hs27)(EC₅₀ μg/mL)
Hexane	300.65 ± 3.54^a	267.73 ± 5.58^a	327.40 ± 3.80^a	11.30 ± 0.68^a
Ethyl acetate	482.23 ± 5.81^b	322.63 ± 4.67^b	363.60 ± 4.26^b	37.32 ± 0.68^b
Methanol	811.07 ± 11.02^c	1264.33 ± 28.38^c	838.93 ± 27.40^c	208.94 ± 2.67^c
Water	1150.97 ± 2.93^d	997.73 ± 14.21^d	1368.00 ± 28.93^d	339.62 ± 2.07^d
Positive controls
Tx	-	88.84 ± 3.76^e	26.08 ± 0.42^e	4.02 ± 0.15^e
AA	2889.59 ± 13.56^e	79.64 ± 2.22^e	22.95 ± 0.50^f	ND
GA	2560.15 ± 28.86^f	ND	ND	ND
Cn	2387.02 ± 46.65^f	31.29 ± 1.11^f	28.73 ± 0.34^g	ND
Qn	ND	46.95 ± 0.58^g	22.43 ± 0.58^f	0.57 ± 0.01^f
PP	ND	ND	ND	1.12 ± 0.08^g

Tx trolox, AA ascorbic acid, GA gallic acid, Cn catechin, Qn quercetin, PP polyphenon-60, DE dried extract, ND not done. Values are mean ± SD (n = 3). The mean values in each column with different letters (a-g) are significantly different (p < 0.05)

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