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Table 4 Effect of solvents extraction on in vivo anti-inflammatory activity of both date seeds

From: Effect of solvents extraction on phytochemical components and biological activities of Tunisian date seeds (var. Korkobbi and Arechti)

  Edema (10–2/mL) (mean ± SD) Edema inhibition (%)
Treatment Dose (mg/kg) 1 h 3 h 5 h 1 h 3 h 5 h
Control   34 ± 1,5 59,5 ± 1,7 68,3 ± 1,09    
KS Methanol extract 100 27,03 ± 1,9 29,26 ± 1,1* 35,01 ± 0,89* 20,5 50,82 48,74
200 23,08 ± 2,8* 24,11 ± 0,8* 30,13 ± 1,04* 32,11 59,47 55,88
300 19,1 ± 1,5** 23,34 ± 1,8** 28,04 ± 1,65* 43,82 60,77 58,94
Aquous extract 100 25,5 ± 1,07 27,12 ± 2,02* 33,37 ± 1,98* 25 54,42 51,14
200 20,17 ± 2,3* 22,02 ± 1,98** 27,52 ± 2,67* 40,67 62,99 59,70
300 17 ± 2,7** 19,69 ± 1,08** 24,6 ± 2,13* 50 66,90 63,98
Acetone extract 80% 100 29,24 ± 2,1 35,17 ± 2,09* 38,14 ± 2,87* 14 40,89 44,15
200 26,18 ± 1,03 29,04 ± 1,98* 34,21 ± 1,89* 23 51,19 49,91
300 21,41 ± 1,75* 26,3 ± 1,91* 32,12 ± 2,09* 37,02 55,79 52,97
Acetone extract 100% 100 30,09 ± 0,89 37,15 ± 2,09 41,07 ± 2,01* 11,5 37,56 39,86
200 27,23 ± 2,87 32,21 ± 2,02* 39,51 ± 1,09* 19,91 45,86 42,15
300 23,35 ± 1,98* 27,5 ± 1,89* 34,21 ± 1,19* 31,32 53,78 49,91
AS Methanol extract 100 27,5 ± 1,76 31,15 ± 1,09* 36,29 ± 1,2* 19,11 47,64 46,86
200 24,41 ± 1,57 27,21 ± 2,08* 32,14 ± 1,14* 28,20 54,26 52,94
300 20,06 ± 1,4* 24,5 ± 2** 30,34 ± 2,03* 41 58,82 55,57
Aquous extract 100 26,18 ± 2,34 28,41 ± 2,02 34,21 ± 3,01* 23 52,25 49,91
200 21,5 ± 2,04* 23,34 ± 1,03* 29,02 ± 1,2* 36,76 60,77 57,51
300 18,05 ± 2,01** 21,7 ± 1,65* 27 ± 2,98* 46,91 63,52 60,46
Acetone extract 80% 100 28,5 ± 1,87 35,17 ± 1,05 38,04 ± 2,07* 16,17 40,89 44,30
200 26,18 ± 1,94 31,97 ± 2,3 35,15 ± 1,84* 23 46,26 48,53
300 23,12 ± 1,87* 28,41 ± 2,03 34,21 ± 1,90* 32 52,25 49,91
Acetone extract 100% 100 30,83 ± 1,02 38,38 ± 1,98 45,24 ± 2,03* 9,32 35,49 33,76
200 29,7 ± 1,09 34,29 ± 1,25 41,17 ± 2,5* 12,64 42,36 39,72
300 25,47 ± 2,01 28,17 ± 1,38 35,05 ± 1,76* 25,08 52,65 48,68
Asl 300 22,29 ± 1,09* 25,33 ± 1,34 31,61 ± 1,87 34,44 57,42 53,71
  1. Values are expressed as mean ± S.E.M. (N = 6); ASL: acetyl salicylate of lysine
  2. KS Korkobbi seed, AS Arechti seed
  3. *p ≤ 0.05 significant from the control. **p ≤ 0.01 significant from the control. ***p ≤ 0.001 significant from the control