Fig. 6
From: Effects of a combination treatment of KD5040 and L-dopa in a mouse model of Parkinson’s disease
Effects of combination treatment on SP expression in the SNr. Immunohistochemical analyses of SP expression in the SNr (a, b). Western blot analyses of SP expression in the SNr (c, d). MPTP mice showed significantly lower SP expression in the SNr, whereas combination treatment significantly increased SP expression in the SNr. C: control, M: MPTP, K: KD5040, LL: low dose of l -dopa (5 mg/kg), ML: medium dose of l -dopa (10 mg/kg). *** p < 0.001 vs. control, ### p < 0.001 and # p < 0.05 vs. MPTP, and ††† p < 0.01 vs. each dose of l -dopa. Error bars represent SEM. Scale bar: 100 μm. SP: substance P; SNr: substantia nigra reticulate