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Table 4 Percentage of CD18 expression activity (%) of neutrophils and monocytes at various concentrations of G. segetum extract and its compounds (Mean ± SEM, n = 3)

From: 4,5,4′-Trihydroxychalcone, 8,8′-(ethene-1,2-diyl)-dinaphtalene-1,4,5-triol and rutin from Gynura segetum inhibit phagocytosis, lymphocyte proliferation, cytokine release and nitric oxide production from phagocytic cells

Sample (μg/mL)

Neutrophils

Monocytes

100

50

6.25

3.125

100

50

6.25

3.125

G. segetum extract

 

82.1 ± 11.9

 

90.0 ± 5.2

 

78.0 ± 8.5

 

84.8 ± 7.4

Rutin

 

88.75 ± 0.49

 

99.35 ± 0.64

 

91.60 ± 1.84

 

91.20 ± 1.56

Gallic Acid

81.33 ± 1.80

 

88.77 ± .41

 

68.60 ± 1.20

 

76.50 ± 2.18

 

4,5,4’-trihydroxy chalcone (3)

 

94.60 ± 0.42

 

93.80 ± .42

 

96.25 ± 2.33

 

97.60 ± 0.85

8,8’-(ethene-1,2-diyl)-dinaphtalene-1,4,5-triol (4)

 

97.80 ± 2.30

 

93.10 ± 4.20

 

79.90 ± 4.50

 

92.30 ± 5.60