Table 1 Characteristics of the included studies.
Study ID | Sample size (n/n) Treatment vs Control | Sex(M/F) | Age, y | Treatment intervetion | Control intervetion | Outcomes | Type of PU GU/DU/CU | Time of Treatment | Follow-up duration | Jadad score | Methodology of RCT | Analysis of baseline balance | Blinding |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nie JT 2016 [8] | 75/75 | 25/50:29/46 | 44. 7 ± 5. 2:45. 1 ± 4. 9 | Xiaojianzhong decoction + liangfu wan + omeprazole + amoxicillin | Omeprazole +amoxicillin | Total effective rate | − | 4w | 2w | 1 | Words of random | Comparability | No |
Shi ZG 2016 [5] | 66/66 | 34/32:35/31 | 38 ± 8.0:37.6 ± 7.9 | Xiaojianzhong decoction + omeprazole +amoxicillin + clarithromycin + clavulanate potassium | Omeprazole +amoxicillin + clarithromycin + clavulanate potassium | Hp eradication rates; recurrence rate | − | 4w | 6w | 2 | Random number table | Comparability | No |
Guo RP 2016 [9] | 78/72 | 42/36:40/32 | 44.3:42.6 | Xiaojianzhong decoction + Jiawei Danshen decoction + omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | Total effective rate; Hp eradication rates; recurrence rate; adverse reaction rate | 19/49/10:18/46/8 | 6w | 6mo | 1 | Words of random | Comparability | No |
Xie DM 2016 [10] | 34/34 | 16/19:20/14 | 38.92 ± 4.26:39.15 ± 4.19 | Jia wei Xiaojianzhong decoction | Omeprazole | Total effective rate; adverse reaction rate | − | 8w | − | 2 | Random number table | Comparability | No |
Cai QP 2016 [11] | 36/36 | 22/14:20/16 | 42.8 ± 4.6:44.0 ± 5.5 | Xiaojianzhong decoction | Omeprazole + amoxicillin | Total effective rate | − | 4w | − | 1 | Words of random | Comparability | No |
Li JL 2016 [12] | 34/34 | 21/13:20/14 | 42.58 ± 4.49:41.96 ± 4.88 | Xiaojianzhong decoction + esomeprazole + amoxicillin + clarithromycin | Esomeprazole + amoxicillin + clarithromycin | Total effective rate; Hp eradication rates; recurrence rate | − | 4w | 1y | 2 | Random number table | Comparability | No |
Li J 2015 [13] | 43/43 | 22/21:25/18 | 60.13 ± 2.79/58.12 ± 1.95 | Huang qi jiangzhong decoction jia jiang + omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | Total effective rate; recurrence rate; adverse reaction rate | − | 8w | 6mo | 1 | Words of random | Comparability | No |
Yang CY 2015 [14] | 87/87 | 46/41:49/38 | 44.9 ± 3.9:47.4 ± 3.5 | Huang qi jiangzhong decoction jia jiang + ranitidine | Ranitidine | Total effective rate; recurrence rate; Hp eradication rates; adverse reaction rate | − | 4w | − | 1 | Words of random | Comparability | No |
Wang HX 2015 [15] | 33/33 | 41/25 | 40.4 ± 8.6 | Huang qi jiangzhong decoction + omeprazole + amoxicillin + clarithromycin + hydrotalcite | Omeprazole + amoxicillin + clarithromycin + hydrotalcite | Total effective rate; recurrence rate | 26/32/10 | 6w | 1y | 2 | Method of random data | Comparability | No |
Li X 2015 [16] | 50/50 | 24/26:23/27 | 50.0 ± 0.5:50.0 ± 0.3 | Xiaojianzhong decoction | Omeprazole | Total effective rate; adverse reaction rate | − | 8w | − | 1 | Words of random | Comparability | No |
Yang ZS 2015 [17] | 75/75 | 25/50:29/46 | 44.7 ± 5. 2:45.1 ± 4.9 | Xiaojianzhong decoction + liangfu wan + omeprazole + amoxicillin | Omeprazole + amoxicillin | Total effective rate | − | 4w | − | 1 | Words of random | Comparability | No |
Han B 2015 [18] | 28/28 | 18/10:19/9 | 33.8 ± 11.8:34.2 ± 12.5 | Jia wei Huang qi jiangzhong decoction + omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | Hp eradication rates | 0/28/0:0/28/0 | 3w | − | 2 | Random number table | Comparability | No |
Wen LQ 2015 [19] | 40/40 | 27/13:26/14 | 44.37 ± 4.18:45.62 ± 4.25 | Xiaojianzhong decoction + omeprazole + amoxicillin | Omeprazole + amoxicillin | Hp eradication rates; recurrence rate | − | 4w | 1y | 2 | Random number table | Comparability | No |
Gao SJ 2015 [20] | 50/50 | 24/26:23/27 | 45.7 ± 5.4:45.2 ± 5.0 | Huang qi jiangzhong decoction jia jiang + omeprazole + hydrotalcite + amoxicillin | Omeprazole + hydrotalcite + amoxicillin | Total effective rate; recurrence rate; adverse reaction rate | 19/31/0:18/32/0 | 6w | 6mo | 1 | Words of random | Comparability | No |
Zhang JJ 2014 [21] | 31/31 | 23/8:20/11 | 40.2 ± 2.9:1.8 ± 1.7 | Xiaojianzhong decoction + liangfu wan + omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | Total effective rate | − | 2w | 4mo | 1 | Words of random | Comparability | No |
Xu Y 2014 [22] | 36/36 | 22/14:13/23 | 47.3:37.2 | Jia wei Xiaojianzhong decoction | Omeprazole | Total effective rate | − | 40d | − | 0 | Registration order | Comparability | No |
Liu CY 2014 [23] | 56/56 | 39/17:37/19 | 71. 68 ± 8. 37:69. 52 ± 7. 63 | Huang qi jiangzhong decoction(Mianjian granule) + rabeprazole | Rabeprazole | Total effective rate | − | 4w | − | 2 | Random number table | Comparability | No |
Wu QM 2014 [24] | 25/25 | 28/22 | 40.3 | Huang qi jiangzhong decoction | Omeprazole + metronidazole +amoxicillin | Total effective rate; recurrence rate | 25/0/0:25/0/0 | 8w | 1y | 1 | Words of random | Comparability | No |
Gan GC 2014 [25] | 53/53 | 29/24:28/25 | 39.4 ± 5.6:40.26 ± 5.1 | Jia wei Xiaojianzhong decoction + Omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | significant efficiency rate; recurrence rate | − | 4w | 1y | 1 | Words of random | Comparability | No |
Xi SY 2013 [26] | 62/20 | 38/24:12/8 | 19 ~ 62:21 ~ 61 | Jia wei Xiaojianzhong decoction | Omeprazole | Total effective rate; adverse reaction rate | − | 8w | − | 2 | Random number table | Comparability | No |
Fan WH 2013 [27] | 56/56 | 32/24:30/26 | 47.18 ± 11. 70:46. 29 ± 11. 30 | Xiaojianzhong decoction + esomeprazole + amoxicillin/ clarithromycin + barking dogs wow ketone | Esomeprazole + amoxicillin/ clarithromycin + barking dogs wow ketone | Total effective rate; Hp eradication rates; recurrence rate | 14/32/10:22/28/16 | 8w | 1y | 2 | Random sequence and registration order | Comparability | No |
Yu B 2013 [28] | 49/49 | 67/31 | 36.24 ± 4.12 | Xiaojianzhong decoction + liangfu wan + omeprazole + clarithromycin + amoxicillin + ranitidine | Omeprazole + clarithromycin + amoxicillin + ranitidine | Total effective rate; Hp eradication rates; recurrence rate | − | 8w | 6mo | 2 | Draw lots | Comparability | No |
Li SH 2013 [29] | 68/68 | 39/29:36/32 | 43.4 ± 5.5:42.6 ± 4.5 | Jia wei Xiaojianzhong decoction | Omeprazole + amoxicillin | Total effective rate; recurrence rate | − | 4w | 1y | 1 | Words of random | Comparability | No |
Wan YH 2013 [30] | 37/37 | 19/18:20/17 | 36.58 ± 3.36:37.81 ± 3.64 | Xiaojianzhong decoction jia jian + omeprazole + clarithromycin + amoxicillin | Omeprazole + clarithromycin + amoxicillin | Total effective rate; Hp eradication rates; recurrence rate; adverse reaction rate | − | 4w | 6mo | 2 | Random number table | Comparability | No |
Wu YJ 2013 [31] | 34/34 | 42/26 | 40.1 ± 5.8 | Huang qi jiangzhong decoction + omeprazole + barking dogs wow ketone + clarithromycin | Omeprazole + barking dogs wow ketone + clarithromycin | Total effective rate; Hp eradication rates; adverse reaction rate | 0/34/0:0/34/0 | 4w | − | 1 | Words of random | Comparability | No |
Si AJ 2013 [32] | 29/29 | 32/26 | 40.3 | Huang qi jiangzhong decoction | • Omeprazole + metronidazole +amoxicillin | Total effective rate; recurrence rate | 29/0/0:29/0/0 | 8w | 1y | 1 | Words of random | Comparability | No |
Wu WG 2013 [33] | 35/22 | 28/29 | 24 ~ 57 | Xiaojianzhong decoction jia jian | Omeprazole + metronidazole + amoxicillin + clarithromycin | Total effective rate | 22/21/14 | 4w | − | 1 | Words of random | Comparability | No |
Bi MY 2013 [34] | 32/31 | 20/12:19/12 | 34.7:36.2 | Huang qi jiangzhong decoction +rabeprazole sodium + hydrotalcite | • Rabeprazole sodium + hydrotalcite | Total effective rate; Hp eradication rates | 10/19/3:8/21/2 | 6w | − | 1 | Words of random | Comparability | No |
Li RD 2012 [35] | 30/30 | 16/14:17/13 | 34.48 ± 2.46:34.67 ± 2.28 | Xiaojianzhong decoction + omeprazole + amoxicillin | Omeprazole + amoxicillin | Total effective rate; Hp eradication rates; recurrence rate; adverse reaction rate | 8/18/4:9/16/5 | 4w | 1y | 1 | Words of random | Comparability | No |
Zou YQ 2012 [36] | 45/45 | 28/17:31/14 | 45.2 ± 5.1:43.2 ± 5.0 | Jia wei Xiaojianzhong decoction + lansoprazole +amoxicillin/clarithromycin + guojiaobi | Lansoprazole +amoxicillin/clarithromycin + guojiaobi | Total effective rate | 10/22/13:14/20/11 | 24w | − | 2 | Random number table | Comparability | No |
Deng YX 2012 [37] | 38/30 | − | − | Huang qi jiangzhong decoction + ranitidine | Ranitidine | Total effective rate; Hp eradication rates | 5/33/0:3/27/0 | 4w | − | 1 | Words of random | Comparability | No |
Li XJ 2012 [38] | 46/40 | 29/17:25/15 | 35.9 ± 11.8:34.1 ± 1.21 | Huang qi jiangzhong decoction + omeprazole + clarithromycin + amoxicillin | • Omeprazole + clarithromycin + amoxicillin | Hp eradication rates | 0/46/0:0/40/0 | 1w | 6w | 1 | Words of random | Comparability | No |
Cao AY 2011 [39] | 72/72 | 45/27:47/25 | 37:36 | • Xiaojianzhong decoction jia jiang + omeprazole + metronidazole +amoxicillin + clarithromycin | Omeprazole + metronidazole + amoxicillin + clarithromycin | Total effective rate | 25/47/0:28/44/0 | 8w | − | 1 | Words of random | Comparability | No |
Dan JK 2011 [40] | 30/30 | 21/9:23/7 | 小于30,30 ~ 50,大于50 | Huang qi jiangzhong decoction + shixiaosan + omeprazole/omeprazole + amoxicillin + clarithromycin | Omeprazole/Omeprazole + amoxicillin + clarithromycin | Total effective rate; Hp eradication rates | − | 6w | − | 1 | Words of random | Comparability | No |
Hu J 2011 [41] | 75/25 | 49/26:18/7 | 18 ~ 65:20 ~ 61 | Jia wei Xiaojianzhong decoction + esomeprazole + amoxicillin/ clarithromycin + furazolidone | Ranitidine + bismuth potassium citrate | Total effective rate; adverse reaction rate | 10/38:10:9/13/3 | 8w | − | 0 | Registration order | Comparability | No |
Jang YH 2011 [42] | 65/65 | 36/29:37/28 | 38.2 ± 7.8:37.9 ± 8.1 | Huang qi jiangzhong decoction + ranitidine | Ranitidine | Total effective rate; recurrence rate | 20/33/12:22/32/11 | 4w | 1y | 1 | Words of random | Comparability | No |
Yi LH 2011 [43] | 50/50 | 32/18:23/27 | 45.9:48.5 | Huang qi jiangzhong decoction + omeprazole + amoxicillin + clarithromycin | Omeprazole + amoxicillin + clarithromycin | Total effective rate | − | 4w | − | 2 | Random number table | Comparability | No |
Wu GL 2010 [44] | 45/45 | 26/19:28/17 | 59.34 ± 21.65:56.99 ± 16.06 | Jia wei Xiaojianzhong decoction | Omeprazole/Omeprazole + amoxicillin | Effective rate; recurrence rate | − | 4w | 1y | 2 | Random number table | Comparability | No |
Wu LN 2010 [45] | 40/32 | 23/17:18/14 | 44.6:43.50 | Jia wei Huang qi jiangzhong decoction | Omeprazole + furazolidone + clarithromycin | Total effective rate; Hp eradication rates; recurrence rate; adverse reaction rate | 18/22:14/18 | 4 or 6w | 1y | 1 | Words of random | Comparability | No |
Li XS 2010 [46] | 45/42 | − | 51 ± 3.4:49 ± 4.8 | Huang qi jiangzhong decoction jia jiang + acupoint application | Omeprazole + metronidazole + amoxicillin | significant efficiency rate; recurrence rate; Hp eradication rates; adverse reaction rate | − | 4w | 1mo | 0 | Registration order | Comparability | No |
Zhu XX 2009 [6] | 22/24 | 15/7:18/6 | 30 ~ 58:28 ~ 56 | Jia wei Jiangzhong decoction + omeprazole + amoxicillin + clarithromycin | Omeprazole + amoxicillin + clarithromycin | Total effective rate | − | 8w | − | 1 | Words of random | Comparability | No |
Cui BS 2009 [47] | 35/35 | 21/14:23/12 | 17 ~ 75:18 ~ 74 | Jia wei Huang qi jiangzhong decoction + clarithromycin + amoxicillin + omeprazole | Omeprazole + amoxicillin + clarithromycin | Total effective rate; adverse reaction rate | 20/15/0:22/13/0 | 4w | − | 0 | Registration order | Comparability | No |
Gao Y2009 [48] | 62/60 | 48/14:47/13 | 43.5:44.6 | Huang qi jiangzhong decoction + famotidine + tinidazole/famotidine + tinidazole + amoxicillin | Famotidine + tinidazole/famotidine + tinidazole + amoxicillin | Total effective rate | 9/48/5:7/47/6 | 6w | − | 1 | Words of random | Comparability | No |
Zhan SL 2009 [49] | 60/36 | 42/18:24/12 | 8 ~ 65:11 ~ 55 | Jia wei Huang qi jiangzhong decoction | Ranitidine | Total effective rate; Hp eradication rates; adverse reaction rate | 21/31/8:13/19/4 | 8w | − | 0 | Registration order | Comparability | No |
Li YL 2009 [50] | 40/34 | 27/13:22/12 | 43:42 | Huang qi jiangzhong decoction + omeprazole + amoxicillin + metronidazole | Omeprazole + amoxicillin + metronidazole | Total effective rate; Hp eradication rates | 18/22:16/18 | 4w | − | 1 | Words of random | Comparability | No |
Pan DJ 2008 [51] | 39/39 | 47/31 | 36.5 | Huang qi jiangzhong decoction + omeprazole + amoxicillin + clarithromycin | Omeprazole + amoxicillin + clarithromycin | Total effective rate; adverse reaction rate | − | 4w | − | 1 | Words of random | Comparability | No |
Nong ZX 2008 [52] | 40/40 | 25/15:23/17 | 25.21 ± 2.32:23.21 ± 2.98 | Huang qi jiangzhong decoction jia jiang + omeprazole + amoxicillin + tinidazole | Omeprazole + amoxicillin + tinidazole | Total effective rate; recurrence rate; Hp eradication rates | 13/20/5:10/25/4 | 8w | 1y | 0 | Registration order | Comparability | No |
Zhou XL 2008 [53] | 45/45 | 24/21:27/18 | 19 ~ 62:18 ~ 64 | Jia wei Huang qi jiangzhong decoction + omeprazole + ranitidine + aluminum hydroxide piece | Omeprazole + ranitidine + aluminum hydroxide piece | Total effective rate | 5/39/1:6/37/2 | 4w | − | 1 | Words of random | Comparability | No |
Zhao XL 2008 [54] | 120/60 | 76/44:44/16 | 41.9 ± 8.9:43.0 ± 8.3 | Huang qi jiangzhong decoction jia jiang | Ranitidine | Total effective rate; Hp eradication rates;adverse reaction rate | − | 4w | − | 0 | Registration order | Comparability | No |
Huang H 2007 [55] | 25/25 | 15/10:18/7 | 43.5 ± 6.5:38.4 ± 6.7 | Jia wei xiaojianzhong decoction | Omeprazole + amoxicillin + metronidazole | Total effective rate; recurrence rate; Hp eradication rates | 6/12/7:9/13/3 | 4w | 1y | 2 | Random number table | Comparability | No |
Wang ZC 2007 [56] | 40/40 | 28/12:27/13 | 41 ± 1.2:40 ± 1.4 | Jia wei Huang qi jiangzhong decoction | • Famotidine + amoxicillin + tinidazole + guojiaobi | Total effective rate; Hp eradication rates; adverse reaction rate | 16/24/0:16/24/0 | 4w | − | 0 | Registration order | Comparability | No |
Gao XX 2006 [57] | 80/80 | 66/14:60/20 | 2 ~ 72:22 ~ 68 | Jia wei Huang qi jiangzhong decoction + omeprazole + amoxicillin + bismuth potassium pitrate | Omeprazole + amoxicillin + bismuth potassium pitrate | Total effective rate | 0/80/0:0/80/0 | 4w | − | 1 | Words of random | No | No |
Chen YJ 2005 [58] | 30/30 | 17/13:20/10 | 45.63 ± 15.1:44.82 ± 18.0 | Huang qi jiangzhong decoction | Ranitidine | Total effective rate | 30/0/0:30/0/0 | 4w | − | 1 | Words of random | Comparability | No |
Tang QJ 2002 [59] | 20/20 | 12/8:13/7 | 36.0 ± 2.4:37.0 ± 1.8 | Jia wei Huang qi jiangzhong decoction | Gentamicin + cimetidine | Total effective rate | 0/20/0:0/20/0 | 1w | − | 1 | Words of random | Comparability | No |
Chai LM 2001 [60] | 56/28 | 31/25:16/12 | 35.1 ± 8.2:33.9 ± 9.8 | Huang qi jiangzhong decoction + ranitidine | Ranitidine | Total effective rate; recurrence rate | 15/29/12:8/14/6 | 4w | 1y | 1 | Words of random | Comparability | No |
Hou AQ 2001 [61] | 100/100 | 58/42:52/48 | 45:50 | Jia wei Huang qi jiangzhong decoction | Amoxicillin + guojiaobi + cimetidine | Total effective rate | 44/36/16:51/42/7 | 2w | 1y | 1 | Words of random | Comparability | No |
Qian CY 2000 [62] | 24/24 | 16/8:17/7 | 40:42 | Huang qi jiangzhong decoction | Ranitidine + amoxycillin + metronidazole | Hp eradication rates; recurrence rate; adverse reaction rate | 0/24/0:0/24/0 | 2w | 1y | 1 | Words of random | Comparability | No |
Chen HX 1997 [63] | 50/50 | 30/20:30/20 | − | Huang qi jiangzhong decoction + omeprazole | Omeprazole | recurrence rate | 0/50/0:0/50/0 | 4w | 1y | 1 | Words of random | No | No |