Fig. 5

The immunohistochemical (IHC) expression of pro-apoptotic proteins; Caspase 9, Apaf-1, FASLG, FADD and anti-apoptotic proteins; Bcl-xl, ESR1 in TH treated tumors compared to the tumors of untreated control. A = +ve control for immunohistochemistry (IHC) analysis, B = −ve control for study (untreated tumor bearing rats), C = 0.2 g/kg TH, D = 1.0 g/kg TH and E = 2.0 g/kg TH. All specimens were examined at X400 microscopic magnification and brown color show antibody positivity. FASLG and FADD showed no expression in tumors of all treatment groups, while tumors in treated groups showed higher expression of pro-apoptotic proteins than those of non-treated control. Legend: TH = Tualang honey