Table 2 Significantly regulated KEGG and Reactome pathways in TC-71 cells treated 24Â h with viscumTT, viscum or TT versus untreated control cells
Extract | Pathway | # Proteins | p-Value | q-Value |
|---|---|---|---|---|
| Â | >Downregulated | |||
 Viscum | Ribosome | 75 | 0.00 | 0.00 |
Transcription | 57 | 0.00 | 9.64 × 10^+3 | |
Translation | 122 | 7.95 × 10^-3 | 1.80 × 10^-1 | |
 TT | Ribosome | 76 | 0.00 | 8.58 × 10^-3 |
Transcription | 59 | 0.00 | 3.18 × 10^-2 | |
Translation | 123 | 7.11 × 10^-3 | 2.10 × 10^-1 | |
 ViscumTT | Ribosome | 76 | 0.00 | 0.00 |
Transcription | 59 | 0.00 | 0.00 | |
Translation | 124 | 5.95 × 10^-3 | 1.20 × 10^-1 | |
| Â | >Upregulated | |||
 Viscum | Aminoacyl-tRNA biosynthesis | 22 | 0.00 | 0.00 |
Proteasome | 35 | 2.96 × 10^-3 | 9.81 × 10^-2 | |
Protein folding | 28 | 2.98 × 10^-3 | 3.89 × 10^-2 | |
PERK regulated gene expression | 10 | 1.27 × 10^-2 | 6.36 × 10^-2 | |
MAP kinase activation in TLR cascade | 8 | 5.64 × 10^-2 | 1.15 × 10^-1 | |
Immune system | 175 | 0.00 | 1.51 × 10^-1 | |
 TT | Aminoacyl-tRNA biosynthesis | 22 | 0.00 | 0.00 |
Proteasome | 35 | 1.08 × 10^-2 | 3.48 × 10^-2 | |
 ViscumTT | Aminoacyl-tRNA biosynthesis | 22 | 0.00 | 0.00 |
Proteasome | 35 | 0.00 | 5.72 × 10^-2 | |
Regulation of apoptosis | 38 | 0.00 | 3.10 × 10^-2 | |
PERK regulated gene expression | 10 | 1.80 × 10^-2 | 6.42 × 10^-2 | |
Immune system | 175 | 3.00 × 10^-3 | 7.35 × 10^-2 | |
Protein folding | 28 | 1.42 × 10^-2 | 7.91 × 10^-2 | |
MAP kinase activation in TLR cascade | 8 | 3.90 × 10^-2 | 7.95 × 10^-2 | |
Apoptosis | 69 | 2.85 × 10^-2 | 1.59 × 10^-1 | |